Principal Engineer: M365 & Copilot Platform Architect

Vertex Pharmaceuticals LLC

Boston (MA)

Hybrid

USD 144,000 - 216,000

Full time

6 days ago
Be an early applicant

Get a reply from this employer

Your resume and cover letter, tailored to exactly what they’re hiring for.

Get past ATS filters

Job summary

Vertex Pharmaceuticals LLC is seeking a Principal Engineer to lead Microsoft 365 Modern Work and Copilot platform initiatives in a Hybrid Boston setting. The role balances hands-on work with strategic leadership, shaping secure, governed delivery across Teams, SharePoint Online, OneDrive, Exchange, and Entra ID.

The ideal candidate will drive Copilot and AI enablement, create robust governance, and collaborate with security, privacy, legal, and compliance teams.

Qualifications

  • Bachelor's degree or equivalent in Information Systems, CS, Engineering, Business, or related discipline.
  • Extensive experience delivering and governing enterprise Microsoft 365 Modern Work capabilities.
  • Experience implementing Copilot, Copilot Studio, AI governance, or related AI productivity capabilities.

Responsibilities

  • Own technical delivery for Modern Work and AI initiatives, including design and change control.
  • Lead escalations, incident management, root cause analysis, and troubleshooting.
  • Lead Copilot and AI enablement, including SharePoint agents, Copilot Studio, and GitHub Copilot.
  • Drive automation and continuous improvement across platforms.
  • Act as technical authority, coordinating sessions and documenting governance and standards.

Skills

Microsoft 365 Expertise
Technical Leadership
Security & Compliance
Copilot/AI Governance
Incident Management

Education

Bachelor's degree in Information Systems / Computer Science / Engineering

Tools

GitHub Copilot
Copilot Studio
Power Automate
Power Apps
SharePoint Online

Job description

Vertex Pharmaceuticals LLC is seeking a Principal Engineer to lead Microsoft 365 Modern Work and Copilot platform initiatives in a Hybrid Boston setting. The role balances hands-on work with strategic leadership, shaping secure, governed delivery across Teams, SharePoint Online, OneDrive, Exchange, and Entra ID.

The ideal candidate will drive Copilot and AI enablement, create robust governance, and collaborate with security, privacy, legal, and compliance teams.

Get your free, confidential resume review.

or drag and drop your file here.

Similar jobs

Similar jobs worth comparing

Lead Architect, Microsoft 365 & Copilot Platforms
Lead Architect, Microsoft 365 & Copilot Platforms

Vertex Pharmaceuticals Incorporated • Boston (MA)

Hybrid
USD 144,000 - 216,000
Principal Engineer, Microsoft 365 & Copilot (Hybrid)
Principal Engineer, Microsoft 365 & Copilot (Hybrid)

Vertex Pharmaceuticals Inc (US) • Boston (MA)

Hybrid
USD 144,000 - 216,000
Medical, dental and vision benefits
Generous paid time off
Educational assistance programs
+3
Lead Architect: Microsoft 365 & Copilot Platforms
Lead Architect: Microsoft 365 & Copilot Platforms

MFS Investments • Boston (MA)

Hybrid
USD 144,000 - 216,000
Annual bonus
Equity awards
Hybrid work model
Principal Engineer, Microsoft 365 and Copilot Platforms
Principal Engineer, Microsoft 365 and Copilot Platforms

Vertex Pharmaceuticals LLC • Boston (MA)

Hybrid
USD 144,000 - 216,000
M365 Modern Workplace Engineer: Copilot & Automation
M365 Modern Workplace Engineer: Copilot & Automation

Nelnet • United States

Remote
USD 75,000 - 120,000
Medical Insurance
Dental Insurance
Vision Insurance
+11
Principal Engineer, Microsoft 365 and Copilot Platforms
Principal Engineer, Microsoft 365 and Copilot Platforms

Vertex Pharmaceuticals Incorporated • Boston (MA)

Hybrid
USD 144,000 - 216,000
Principal Engineer, Microsoft 365 and Copilot Platforms
Principal Engineer, Microsoft 365 and Copilot Platforms

Boston While Black • Boston (MA)

Hybrid
USD 144,000 - 216,000
Annual bonus
Equity awards
Hybrid work model
Microsoft 365 & Copilot Architecture Lead
Microsoft 365 & Copilot Architecture Lead

SwitchThink Solutions LLC • Phoenix (AZ)

Hybrid
USD 120,000 - 180,000
M365 & Copilot Architect II — Remote Modern Workplace Lead
M365 & Copilot Architect II — Remote Modern Workplace Lead

Insight • Chandler (AZ)

Remote
USD 120,000 - 160,000
Remote work in AZ
Global travel up to 30 days/year
Microsoft 365 Platform Engineer: Copilot & Automation Architect
Microsoft 365 Platform Engineer: Copilot & Automation Architect

Applied Materials • California (MO)

On-site
USD 122,000 - 168,000