Principal Computational Biologist — Target Discovery

gordian-biotechnology; South San Francisco (CA); On-site; USD 170,000 - 230,000; Full time

Benefits offered by this job

Equity

Health insurance

401k with match

Onsite lunch

Onsite gym

Remote work flexibility

Job summary

Gordian Biotechnology in South San Francisco is seeking a Principal Computational Biologist to shape how large-scale perturbation data informs target prioritization and MOA exploration. You will define standardized analytical frameworks, work with disease experts on forward planning, and push methodological advances across the computational team.

You will apply deep ML and single-cell analytics, integrate multi-omics data, and collaborate with wet-lab groups to ensure rigorous, translatable

Qualifications

• Ph.D. in Bioinformatics, Computational Biology, Statistics, Computer Science or related quantitative field.
• 2+ years of hands-on post-graduate industry experience in computational biology.
• Experience applying computational biology to single-cell transcriptomic data in preclinical or translational settings.
• Experience in target prioritization, mechanism-of-action investigation, biomarker discovery, or validation toward clinical translation.
• Strong in R and/or Python and fluency with major single-cell ecosystems (Seurat, Scanpy).
• Experience leveraging public resources (GTEx, UK Biobank) and other omics datasets for MOA and target prioritization.

Responsibilities

• Define and standardize statistical frameworks, QC criteria, and analyses for the computational team.
• Lead forward screen planning with disease-area experts and drive validation strategies.
• Develop interpretable analytical methods and feature development for perturbation screening pipelines.
• Integrate multi-omics data (proteomics, human genetics) to strengthen translatability.
• Contribute to deploying modular, semi-automated QC/analysis frameworks and collaborate with wet-lab groups.

Skills

R

Python

Single-cell analysis

Machine learning

Data integration

Interdisciplinary communication

Education

Ph.D. in Bioinformatics/Computational Biology/Statistics/Computer Science

Tools

Seurat

Scanpy

GTEx/UK Biobank resources

Job description

Gordian Biotechnology in South San Francisco is seeking a Principal Computational Biologist to shape how large-scale perturbation data informs target prioritization and MOA exploration. You will define standardized analytical frameworks, work with disease experts on forward planning, and push methodological advances across the computational team.

You will apply deep ML and single-cell analytics, integrate multi-omics data, and collaborate with wet-lab groups to ensure rigorous, translatable