Principal CAR‑T Scientist (Immunology & Cell Therapy)

Novartis AG; Cambridge (AL); On-site; USD 109,000 - 222,000; Full time

Job summary

Novartis in Cambridge, MA is seeking a PhD scientist with 1–2 years of relevant experience to advance CAR‑T cell therapies within Oncology Immune Therapeutics. You will design, generate, and test CAR constructs and collaborate with cross‑functional teams to translate findings into clinical opportunities.

The role emphasizes hands‑on engineering, data generation, and high‑quality documentation, with opportunities to contribute to regulatory submissions and future trials.

Qualifications

• PhD in immunology, cell biology, molecular biology, bioengineering or related field with 1–2 years of relevant research.
• Hands-on CAR-T engineering or engineered T-cell experience.
• Experience with multicolor flow cytometry (FACS) and cytokine profiling (ELISA, MSD, Luminex).
• Experience isolating immune cells and culturing primary human T cells.
• Experience designing and generating lentiviral CAR constructs and interpreting functional data.

Responsibilities

• Design and execute research to advance next‑generation CAR‑T approaches.
• Generate and evaluate complex lentiviral CAR constructs for logic‑gated CAR‑T.
• Perform functional testing and develop novel analytical methods.
• Execute cell‑line engineering to evaluate function and inform construct selection.
• Analyze data across engineering, in vitro, and in vivo pharmacology to prioritize leads.
• Drive projects to meet timelines with high data quality and integrity.
• Follow SOPs, document experiments meticulously, and maintain electronic lab records.
• Contribute to drafting technical documents for regulatory submissions.
• Present results and recommendations to cross‑functional teams and leadership.

Skills

CAR‑T engineering

T‑cell biology

Flow cytometry

Cytokine profiling

Experimental design

Team collaboration

Data interpretation

Education

PhD in immunology

PhD in cell biology

PhD in molecular biology

Tools

Lentiviral constructs

Primary human T cell culture

Job description

Novartis in Cambridge, MA is seeking a PhD scientist with 1–2 years of relevant experience to advance CAR‑T cell therapies within Oncology Immune Therapeutics. You will design, generate, and test CAR constructs and collaborate with cross‑functional teams to translate findings into clinical opportunities.

The role emphasizes hands‑on engineering, data generation, and high‑quality documentation, with opportunities to contribute to regulatory submissions and future trials.