CAR-T Lead Scientist: Next-Gen Cell Therapies

Novartis Group Companies; Cambridge (MA); On-site; USD 109,000 - 222,000; Full time

Job summary

Novartis Group of Companies in Cambridge, MA seeks a PhD scientist (1–2 years) to join a multidisciplinary CAR-T cell therapeutics discovery team in Oncology Immune Therapeutics. You will engineer CAR-T constructs, perform functional testing, and generate high-quality data to inform clinical translation.

The role emphasizes cross-functional collaboration, rigorous documentation, and contributing to regulatory submissions while advancing next-generation CAR-T platforms towards potential clinical

Qualifications

• PhD in immunology, cell biology, molecular biology, bioengineering, or related field with 1–2 years of experience.
• Hands-on CAR-T engineering or engineered T-cell experience.
• Experience with ex vivo cell characterization using multicolor flow cytometry and cytokine profiling methods.

Responsibilities

• Design and execute research to advance next-generation CAR-T approaches.
• Design, generate, and evaluate complex lentiviral CAR constructs.
• Perform functional testing and optimize CAR-T cells; develop new analytical methods.
• Engineer cell lines to create models and inform construct selection.
• Integrate data across engineering, in vitro, and in vivo studies to prioritize candidates.
• Drive projects to meet timelines with high data quality and traceability.
• Record data meticulously and follow SOPs; contribute to technical documents and regulatory submissions.
• Present results and recommendations to cross-functional teams and leadership.

Skills

CAR-T engineering

T-cell biology

Flow cytometry

Lentiviral construct design

Data analysis

Education

PhD in immunology or related

Tools

FACS

Cytokine profiling assays

Lentiviral vector design

Job description

Novartis Group of Companies in Cambridge, MA seeks a PhD scientist (1–2 years) to join a multidisciplinary CAR-T cell therapeutics discovery team in Oncology Immune Therapeutics. You will engineer CAR-T constructs, perform functional testing, and generate high-quality data to inform clinical translation.

The role emphasizes cross-functional collaboration, rigorous documentation, and contributing to regulatory submissions while advancing next-generation CAR-T platforms towards potential clinical