Principal AI/ML & Optimization Scientist (Clinical Ops)

Johnson & Johnson Innovative Medicine; Cambridge (MA); On-site; USD 69,000 - 119,000; Full time

Benefits offered by this job

Annual bonus

Vacation days

Parental leave

Bereavement leave

Well-being reimbursement

Insurance plans

Job summary

Johnson & Johnson Innovative Medicine is seeking a Principal Data Scientist – AI/ML and Optimization to lead advanced analytics for global development. You will design ML and optimization pipelines supporting enrollment forecasting, cost estimation, and country/site selection, with a primary location in Madrid and potential consideration of other sites.

You will advance GenAI and NLP methods to extract insights from protocols, harmonize data from real-world sources, and develop stochastic

Qualifications

• PhD in a quantitative discipline (e.g., CS, ECE, biostatistics, health economics, biomedical informatics, applied mathematics)
• 5+ years of industry experience delivering data science projects with ML, optimization, NLP, GenAI
• Hands-on with multi-modal ML, stochastic simulations for time-series forecasting

Responsibilities

• Conceive, develop, and implement ML, multi-objective optimization, GenAI solutions to support clinical trial operations
• Leverage RWD and cost data to build ML models and optimization engines for data-driven decision making
• Develop predictive ML models for time-series outcomes and KPIs
• Solve multi-objective optimization problems to trade off cost, timelines, patient burden, quality, and efficiency
• Integrate predictive modeling with optimization to evaluate scenarios and advise on strategies
• Build explainable decision-support systems for proactive planning and risk identification
• Adapt LLMs for information extraction and protocol comparison; support trial data harmonization

Skills

PhD in quantitative field

ML/Optimization

GenAI

MLOps

Python

SQL

Clinical data

Education

PhD in quantitative discipline

Tools

MLflow

Kedro

Git/GitLab/CI

Jenkins

PyMC/Optuna

Job description

Johnson & Johnson Innovative Medicine is seeking a Principal Data Scientist – AI/ML and Optimization to lead advanced analytics for global development. You will design ML and optimization pipelines supporting enrollment forecasting, cost estimation, and country/site selection, with a primary location in Madrid and potential consideration of other sites.

You will advance GenAI and NLP methods to extract insights from protocols, harmonize data from real-world sources, and develop stochastic