Postdoctoral Scientist: Ophthalmology & Gene Therapy

University of Pennsylvania Perelman School of Medicine; Pennsylvania; On-site; USD 52,000 - 62,000; Full time

Job summary

University of Pennsylvania is seeking a highly motivated, full-time postdoctoral scientist in the Ophthalmology Department to join a collaborative research lab led by Dr. Lucie Guo.

The role focuses on molecular biology, epigenetics, gene therapy, and ophthalmology, with mentorship in experimental design, scientific communication, grant writing, and career development. Responsibilities include independent research using CRISPR, cell culture, molecular assays, animal studies, data analysis,

Qualifications

• PhD in biology, biochemistry, biophysics, pharmacology, molecular biology, genetics, neuroscience, vision science, biomedical engineering, or related field.
• Strong foundation in experimental design, data analysis, and scientific communication.

Responsibilities

• Conduct independent laboratory research using molecular cloning, cell culture, transfection, CRISPR, flow cytometry, and biochemical assays.
• Perform animal studies with mouse models, tissue collection, ocular imaging, and histologic/molecular analyses.
• Design and optimize experiments, develop protocols, and troubleshoot challenges.
• Maintain accurate laboratory records and ensure data quality and reproducibility.
• Present progress at lab meetings and seminars; prepare figures and manuscripts for publication.
• Write fellowship, grant, and other funding applications.
• Mentor junior researchers and contribute to a collaborative lab environment.

Skills

Molecular cloning

CRISPR editing

Cell culture

Transfection

Flow cytometry

Data analysis

Scientific communication

Experiment design

Mentoring

Education

PhD in biology or related field

Tools

Microscopy

AAV vector design

Job description

University of Pennsylvania is seeking a highly motivated, full-time postdoctoral scientist in the Ophthalmology Department to join a collaborative research lab led by Dr. Lucie Guo.

The role focuses on molecular biology, epigenetics, gene therapy, and ophthalmology, with mentorship in experimental design, scientific communication, grant writing, and career development. Responsibilities include independent research using CRISPR, cell culture, molecular assays, animal studies, data analysis,