Postdoctoral Scientist Ophthalmology Research Gene Therapy

University of Pennsylvania; Erie (Erie County); On-site; USD 55,000 - 70,000; Full time

Job summary

University of Pennsylvania's Department of Ophthalmology seeks a highly motivated postdoctoral scientist to join a collaborative lab focused on molecular biology, epigenetics, gene therapy, and ophthalmology under Dr. Lucie Guo.

The role offers mentorship in experimental design, scientific communication, grant writing, and career development. The successful candidate will conduct independent research using CRISPR, cell culture, animal models, and various molecular assays, while contributing to

Qualifications

• PhD in biology, biochemistry, biophysics, pharmacology, molecular biology, genetics, neuroscience, vision science, biomedical engineering, or related field.

Responsibilities

• Conduct independent laboratory research using molecular cloning, cell/tissue culture, transfection, CRISPR-based genome engineering, flow cytometry, and molecular/biochemical assays.
• Perform animal studies, including mouse models, tissue collection, ocular imaging, and histologic and molecular analyses.
• Design rigorous experiments, develop research protocols, and troubleshoot challenges independently.
• Maintain accurate records and ensure data quality and reproducibility.
• Analyze and interpret data using quantitative and statistical methods.
• Review literature and integrate new concepts into projects.
• Present progress at lab meetings, seminars, and discussions.
• Prepare figures, manuscripts, abstracts for peer-reviewed journals and funders.
• Write fellowship, grant and funding applications.
• Present findings at conferences locally, nationally, and internationally.
• Collaborate with clinicians and researchers across disciplines.
• Mentor junior researchers and trainees; contribute to a productive lab environment.
• Pursue individualized research and career goals with PI mentorship.

Skills

Experimental design

Data analysis

Scientific communication

Grant writing

Mentoring

Collaboration

Education

PhD in biology/biochemistry/biophysics/pharmacology/molecular biology/genetics/neuroscience/vision science/biomedical engineering

Tools

CRISPR-based genome editing

PCR/qPCR

Western blotting

Immunofluorescence

Mammalian cell culture

Transfection

AAV viral vectors

Flow cytometry

Microscopy

Histology

Job description

University of Pennsylvania's Department of Ophthalmology seeks a highly motivated postdoctoral scientist to join a collaborative lab focused on molecular biology, epigenetics, gene therapy, and ophthalmology under Dr. Lucie Guo.

The role offers mentorship in experimental design, scientific communication, grant writing, and career development. The successful candidate will conduct independent research using CRISPR, cell culture, animal models, and various molecular assays, while contributing to