Postdoctoral Scientist

Upenn; Philadelphia (Philadelphia County); On-site; USD 60,000 - 75,000; Full time

Job summary

The Department of Ophthalmology at University of Pennsylvania invites applications for a full-time postdoctoral scientist to join a collaborative laboratory led by Dr. Lucie Guo.

The position focuses on molecular biology, epigenetics, gene therapy, and vision science, with mentorship in experimental design, grant writing, and career development. Responsibilities include independent research using cloning, CRISPR genome editing, cell culture, and animal studies with mouse models.

Qualifications

• PhD in biology, biochemistry, biophysics, pharmacology, molecular biology, genetics, neuroscience, or related field.
• Strong background in experimental design, data analysis and scientific communication.
• Publication record and independent research interest preferred.

Responsibilities

• Conduct independent laboratory research using cloning, CRISPR, cell culture and assays.
• Perform animal studies with mouse models, tissue collection and imaging.
• Design and optimize experiments; troubleshoot technical challenges.
• Maintain organized records, ensure data quality and reproducibility.
• Analyze data with appropriate statistics and present findings at meetings.
• Prepare figures, manuscripts and grant applications; mentor junior researchers.
• Collaborate with clinicians and researchers across disciplines.

Skills

Molecular biology techniques

PCR

CRISPR genome editing

Cell culture

Transfection

Animal research

Mouse models

Immunofluorescence

Flow cytometry

Data analysis

Education

PhD in biology/biochemistry/biophysics/neuroscience

Job description

University of Pennsylvania: Postdoctoral Positions: Perelman School of Medicine Postdoctoral

Location

University of Pennsylvania - Perelman School of Medicine

Open Date

Aug 12, 2026

Description

The Department of Ophthalmology is seeking a highly motivated, full-time postdoctoral scientist to join a dynamic and collaborative research laboratory under the direction of the Principal Investigator (Dr. Lucie Guo, MD PhD). The successful candidate will drive to innovative research at the intersection of molecular biology, epigenetics, gene therapy, and ophthalmology while receiving mentorship in experimental design, scientific communication, grant writing, and career development.

Primary responsibilities include:

• Conduct independent laboratory research using techniques such as molecular cloning, cell and tissue culture, transfection, CRISPR-based genome engineering, quantitative flow cytometry, and molecular and biochemical assays
• Perform animal studies, including work with mouse models, tissue collection, ocular imaging, and histologic and molecular analyses
• Design rigorous experiments, develop and optimize research protocols, and troubleshoot technical challenges independently
• Maintain accurate and organized laboratory records and ensure the quality, reproducibility, and appropriate documentation of experimental data
• Analyze and interpret research findings using appropriate quantitative and statistical methods
• Review relevant scientific literature and integrate emerging concepts and technologies into ongoing research projects
• Present research progress and findings regularly at laboratory meetings, departmental seminars, and collaborative research discussions
• Prepare figures, manuscripts, abstracts, and other scientific materials for publication in peer-reviewed journals
• Write fellowship, grant, and other funding applications
• Present research findings at local, national, and international scientific conferences
• Collaborate effectively with laboratory members, clinicians, and research partners across disciplines
• Assist with the training and mentorship of junior researchers, including research staff, graduate students, medical students, and undergraduate students
• Contribute to maintaining an organized, collegial, and productive laboratory environment
• Participate in professional-development activities and work with the Principal Investigator to establish and pursue individualized research and career goals

Qualifications

Qualified applicants should hold a PhD in biology, biochemistry, biophysics, pharmacology, molecular biology, genetics, neuroscience, vision science, biomedical engineering, or a related field. Candidates should have a strong foundation in experimental design, data analysis, scientific communication, and the interpretation of research findings.

Prior experience in one or more of the following areas is highly desirable:

• Molecular biology techniques, including molecular cloning, PCR, quantitative PCR, Western blotting, and immunofluorescence
• Mammalian cell and tissue culture, transfection, and the development or use of cell-based assays
• CRISPR-based genome editing or gene regulation, including guide RNA design and validation
• Viral vector design, production, or application, particularly adeno-associated viral vectors
• Animal research, including experience with mouse models, tissue collection, genotyping, injections, imaging, or surgical procedures
• Microscopy, histology, image analysis, and quantitative data analysis

The ideal candidate will be highly motivated, organized, intellectually curious, and capable of working both independently and collaboratively. Strong written and oral communication skills, careful attention to experimental rigor and reproducibility, and a commitment to maintaining accurate research records are essential. Applicants should also demonstrate the ability to manage multiple projects, troubleshoot technical challenges, contribute constructively to a collaborative laboratory environment, and mentor junior researchers. A strong publication record and demonstrated interest in pursuing an independent scientific or academic career are preferred.

The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state, or local law.