Postdoctoral Scientist, AAV Capsids & CNS Targeting

Broad Institute; Cambridge (MA); On-site; USD 60,000 - 75,000; Full time

Job summary

The Deverman lab at the Broad Institute of MIT and Harvard is seeking a postdoctoral researcher or research scientist to join a multidisciplinary effort focused on developing AAV vectors for targeted gene expression in CNS neuronal populations. The role includes project planning, bench work, reporting results, and contributing to manuscripts and presentations.

You will develop high-throughput selection methods for capsids, apply gene delivery in vivo and in vitro, perform standard molecular

Qualifications

• 0-1+ years of related experience.
• A PhD in molecular biology, neuroscience, or related discipline.
• Experience with molecular biology techniques.
• Familiarity with NGS, high-throughput screening, immunohistochemistry/in situ hybridization, and production of gene delivery vectors is desirable.
• Hands-on experience with stereotaxic injections.
• Bioinformatics and statistics are helpful but not required.
• Outstanding interpersonal and communication skills.
• Proven ability to work within a large cross-disciplinary collaboration in a fast-paced environment.
• Excellent organizational and time management skills.

Responsibilities

• Develop, refine and apply high-throughput selection and screening methods for capsids and gene expression systems.
• Apply gene delivery strategies in vivo and in vitro.
• Use molecular biology techniques for plasmid construction, PCR, qPCR, RNA/DNA extraction, and NGS.
• Produce, purify and evaluate AAV.
• Troubleshoot and participate in new technology evaluation and implementation.
• Document, compile, and analyze data.
• Present results at team meetings and contribute to manuscripts and reports.
• Supervise activities of one or more research associates.
• Collaborate closely to design, implement, and troubleshoot essential experiments.

Skills

Molecular biology techniques

Team collaboration

Scientific communication

Education

PhD in molecular biology or neuroscience

Tools

NGS

PCR

qPCR

In situ hybridization

AAV production

Job description

The Deverman lab at the Broad Institute of MIT and Harvard is seeking a postdoctoral researcher or research scientist to join a multidisciplinary effort focused on developing AAV vectors for targeted gene expression in CNS neuronal populations. The role includes project planning, bench work, reporting results, and contributing to manuscripts and presentations.

You will develop high-throughput selection methods for capsids, apply gene delivery in vivo and in vitro, perform standard molecular