Postdoctoral Scientist - AAV Vector Engineering

Initial Therapeutics, Inc.

San Diego (CA)

On-site

USD 58,000 - 123,200

Full time

14 days+

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Job summary

Lilly in San Diego is seeking a Postdoctoral Research Scientist to join the Biotechnology Discovery Research organization for a two-year fellowship focused on receptor-mediated enhancement of AAV gene delivery through capsid engineering.

The role offers training in viral vector engineering, opportunities for publications, and collaboration across gene therapy and analytical teams; requires a PhD and hands-on molecular biology and cell culture experience.

Qualifications

PhD in Molecular Biology, Cell Biology, Biochemistry, Virology, or related life sciences discipline.
Proficiency in mammalian cell culture and standard molecular biology DNA manipulation techniques.
Experience with quantitative nucleic acid analysis (qPCR or digital PCR).
Authorized to work in the United States on a full-time basis; Lilly will not sponsor work authorization or visas.

Responsibilities

Design, clone, produce, and purify engineered AAV vectors with targeting modifications.
Perform vector quality control including titering (digital PCR), purity assessment, and particle integrity analysis.
Execute cell-based binding, internalization, and transduction assays using flow cytometry and confocal microscopy.
Perform mechanistic trafficking studies including endosomal escape, capsid uncoating, nuclear entry, and genome processing.
Integrate experimental data to establish structure-activity relationships and characterize enhancement mechanisms.
Maintain rigorous experimental documentation in electronic lab notebooks.
Present research at scientific meetings and prepare manuscripts for publication (anticipated 1-2 first-author publications).