Postdoctoral Researcher - Physiology

The Medical College of Wisconsin, Inc.; Wauwatosa (WI); On-site; USD 50,000 - 75,000; Full time

Benefits offered by this job

Healthcare coverage

Tuition reimbursement

Paid parental leave

On-campus fitness facilities

Job summary

The Xiao Lab in the Department of Physiology at MCW seeks a highly motivated postdoctoral fellow to join an interdisciplinary program studying the genetic and epigenetic basis of cardiometabolic diseases. We integrate experimental and computational approaches to translate discoveries into new strategies for prediction, prevention, and treatment.

The successful candidate will conduct physiological studies using mouse models and analyze mouse and patient-derived cells and tissues with omics

Qualifications

• PhD or MD in physiology, genetics, genomics, or related field.
• Experience with mouse models and mammalian cell culture preferred.
• Strong molecular biology and biochemistry skills; immunoblotting a plus.

Responsibilities

• Lead projects on genetics, epigenetics, and inter-organ crosstalk in cardiometabolic diseases.
• Perform physiological studies using mouse models and human tissues.
• Generate and analyze large-scale omics datasets (single-cell, spatial, transcriptomics, proteomics).
• Prepare manuscripts, progress reports and grant applications; present at meetings.
• Mentor trainees and contribute to a collaborative lab environment.

Skills

Mouse models

Mammalian cell culture

Molecular biology

Biochemistry

Cell biology techniques

DNA/RNA extraction

Immunoblotting

R

Python

Scientific communication

Education

PhD or MD in a related field

Tools

R

Python

Job description

SummaryThe Xiao Lab in the Department of Physiology at the Medical College of Wisconsin is seeking a highly motivated postdoctoral fellow to join an interdisciplinary research program investigating the genetic and epigenetic basis of cardiometabolic diseases, including obesity, metabolic liver disease, and cardiovascular disease. We integrate experimental and computational approaches to understand disease mechanisms and aim to translate our discoveries into new strategies for the prediction, prevention, and treatment of cardiometabolic disorders. The successful candidate will conduct physiological studies using mouse models and analyze mouse and patient-derived cells and tissues using comprehensive omics approaches, including functional genomics, single-cell and spatial omics, CRISPR-based screening, and proteomics. The goal of this research is to identify the genes, genetic variants, regulatory pathways, and cellular mechanisms that drive the development and progression of cardiometabolic disease.Primary ResponsibilitiesLead research projects investigating the genetics, epigenetics, and inter-organ crosstalk associated with cardiometabolic diseases.Conduct physiological studies using genetically modified and diet-induced mouse models of obesity and cardiometabolic disease.Perform molecular and cellular experiments using mouse and human tissues/cells, including cloning, PCR, immunoblotting, and reporter assays.Generate, analyze, and interpret large-scale functional genomic, single-cell and spatial omics, transcriptomic, and proteomic datasets.Prepare manuscripts, scientific presentations, progress reports, and grant applications.Present research findings at laboratory meetings and scientific conferences.Mentor trainees, as appropriate, and contribute to a highly interactive and collaborative research environment.Other duties as assigned.Knowledge – Skills – AbilitiesExperience with mouse models and/or mammalian cell culture.Hands-on experience with molecular biology, biochemistry, and cell biology techniques, including DNA and RNA extraction and immunoblotting.Experience with functional genomics and single-cell omics is preferred.Experience analyzing data using R and/or Python is preferred.Strong written and oral communication skills and the ability to work effectively in a collaborative research environment.A publication record demonstrating research productivity and scientific excellence.QualificationsMinimum Required Education: PhD in a scientific field or MDMinimum Required Experience: 0 YearsPreferred Education: PhD or MD/PhD in physiology, cell biology, molecular biology, biochemistry, genetics, genomics, or a related field.Preferred Experience: Mouse models and/or mammalian cell culture; molecular biology, biochemistry, and cell biology techniques, and functional genomics and single-cell omics; bioinformatics.Physical RequirementsWork requires occasionally lifting moderate weight materials, standing, or walking continuously.Work EnvironmentOccasional exposure to dust, noise, temperature changes, or contact with water or other liquids. Work is performed in an environmentally controlled environment.Sensory AcuityAbility to detect and translate speech or other communication required. May occasionally require the ability to distinguish colors and perceive relative distances between objects.Why MCW?Outstanding Healthcare Coverage, including but not limited to Health, Vision, and Dental. Along with Flexible Spending options403B Retirement PackageCompetitive Vacation and Paid Holidays offeredTuition ReimbursementPaid Parental LeaveEmployee & Family Assistance Program (EFAP)Pet InsuranceOn campus Fitness Facility, offering onsite classesAdditional discounted rates on items such as: Select cell phone plans, local fitness facilities, Milwaukee recreation and entertainment etc.For a brief overview of our benefits see: Benefits OverviewFor a full list of positions see: MCW CareersAt MCW all of our endeavors, from our internal operations to our interactions with our partners, are driven by our shared organizational values: Caring – Collaborative – Curiosity – Inclusive – Integrity – Respect. We are committed to fostering an inclusive environment that values diversity in backgrounds, experiences, and perspectives through merit-based processes and in alignment with all applicable laws. We believe that embracing human differences is critical to realize our vision of a healthier world, and we recognize that a healthy and thriving community starts from within. Our values define who we are, what we stand for and how we conduct ourselves at MCW. If you believe in embracing individuality and working together according to these principles to improve health for all, then MCW is the place for you. For more information, please visit our institutional website.MCW as an Equal Opportunity Employer and Commitment to Non-Discrimination:The Medical College of Wisconsin (MCW) is an Equal Opportunity Employer. We are committed to fostering an inclusive community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual's race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, or military status. Employees, students, applicants or other members of the MCW community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic.