Postdoctoral position in research on myelination

MGH and ACP; Madison (WI); On-site; USD 50,000 - 65,000; Full time

Job summary

A leading research institution in Madison is offering a postdoctoral position focused on the cellular and molecular basis of demyelination and remyelination. Candidates should have an MD or PhD in neuroscience with expertise in animal models and imaging techniques. This role involves using RNAseq and MRI to study myelin repair mechanisms. Strong proficiency in English is required.

Qualifications

• MD or equivalent and/or a PhD in neuroscience; preferably background in glial cell biology.
• Expertise in one or more of the following: animal models, imaging, immunolabeling, molecular biology techniques including RT PCR and RNA isolation.
• Applicants must be fluent in spoken and written English.
• Submit CV, brief summary of research background, and three referees' contacts.

Responsibilities

• Study the cellular and molecular basis of demyelination and remyelination in a large animal model.
• Identify the cellular response in the optic nerve and spinal cord.
• Determine the cells responsible for large-scale remyelination.
• Use RNAseq to identify key molecular players.
• Carry out MRI to define imaging parameters of myelin repair.

Skills

Fluent in spoken and written English

Animal models expertise

Imaging techniques

Immunolabeling

Molecular biology techniques

RNAseq analysis

Education

MD or equivalent and/or PhD in neuroscience

Tools

RNAseq

RT PCR

MRI

Job description

Postdoctoral position in research on myelination

University of Wisconsin-Madison

Madison, Wisconsin

Overview

An NMSS funded postdoctoral fellowship is available in the laboratory of Dr. Ian D. Duncan to study the cellular and molecular basis of demyelination and remyelination in a unique large animal model. In this disease, the entire CNS is involved and remyelination occurs spontaneously yet can be manipulated. More prolonged disease leads to some loss of axons in the spinal cord. We plan to identify the cellular response in both the optic nerve and spinal cord and identify differences that may explain the more severe disease in the optic nerve. We wish to determine the cell or cells responsible for the large-scale remyelination. We will use RNAseq to identify the key molecular players in both phases of disease. MRI will be carried out during disease and remyelination to define imaging parameters of myelin repair and axon loss.

Responsibilities

• Study the cellular and molecular basis of demyelination and remyelination in a large animal model.
• Identify the cellular response in the optic nerve and spinal cord and investigate differences that may explain the more severe disease in the optic nerve.
• Determine the cell or cells responsible for large-scale remyelination.
• Use RNAseq to identify key molecular players in both phases of disease.
• Carry out MRI during disease and remyelination to define imaging parameters of myelin repair and axon loss.

Qualifications

• MD or equivalent and/or a PhD in neuroscience; preferably background in glial cell biology.
• Expertise in one or more of the following: animal models, imaging, immunolabeling, molecular biology techniques including RT PCR and RNA isolation.
• Applicants must be fluent in spoken and written English.
• Applicants should submit a CV, brief summary of their research background and names and contacts of three referees.