Postdoctoral Fellow - Neurology Research

Ionis Pharmaceuticals, Inc.; Carlsbad (CA); On-site; USD 65,000 - 87,000; Full time

Job summary

Ionis Pharmaceuticals, Inc. in Carlsbad, California is seeking a Postdoctoral Fellow to study cellular and molecular mechanisms of white matter injury and repair in the Neurology Research group.

The role involves developing cellular and animal models to validate therapeutic targets that promote oligodendrocyte maturation and remyelination. Applicants should have a PhD in Neurobiology or related field, strong publication records, and experience with OMICS and molecular biology techniques.

Qualifications

• PhD in Neurobiology, Cell Biology, or related field with strong peer‑reviewed publications.
• Desirable background in oligodendrocyte biology, myelination, or developmental neuroscience.
• Experience with human iPSC culture, primary neural cultures, or advanced in vitro models.
• Experience with transcriptomics, single-cell RNA sequencing, or other OMICS approaches.
• Experience with molecular biology techniques including qPCR, RNA analysis and imaging.

Responsibilities

• Design and execute research on mechanisms of white matter injury and repair.
• Develop cellular and animal models to study disease biology and therapeutic hypotheses.
• Use molecular, imaging, and OMICS approaches to identify and validate targets.
• Analyze data and communicate findings to multidisciplinary teams.
• Publish in peer‑reviewed journals and present at meetings.

Skills

Communication skills

Team collaboration

Problem solving

Independent work

Education

PhD in Neurobiology or related field

Tools

Single-cell RNA sequencing

qPCR

Confocal microscopy

OMICS approaches

Job description

Postdoctoral Fellow - Neurology Research

Job Category: CSO & IONARPA - Ionis

Requisition Number: IONIS004012

• Posted : July 30, 2026
• Full-Time

Locations

Showing 1 location

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals.

At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees.

With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive.

We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!

POSTDOCTORAL FELLOW – NEUROLOGY RESEARCH

SUMMARY:

We are seeking a highly motivated and exceptional scientist to join our Neurology Research group as a Postdoctoral Fellow investigating the cellular and molecular mechanisms underlying white matter injury and repair. The successful candidate will develop and apply innovative cellular and animal models to identify and validate therapeutic targets that promote oligodendrocyte maturation and remyelination. This position offers an exciting opportunity to conduct innovative research in a multidisciplinary RNA therapeutics environment and contribute to the development of novel therapies for neurological disorders.

WORK LOCATION: Onsite Carlsbad

RESPONSIBILITIES

• Design and execute innovative research to investigate mechanisms underlying white matter injury and repair.
• Develop and apply cellular and animal models to study disease biology and evaluate therapeutic hypotheses.
• Employ molecular, cellular, imaging, and OMICS approaches to identify and validate novel therapeutic targets.
• Analyze, interpret, and communicate experimental findings to multidisciplinary project teams.
• Publish research in peer-reviewed journals and present findings at internal and external scientific meetings.

REQUIREMENTS

• A Ph.D. in Neurobiology, Cell Biology, or a related discipline with a strong publication record in peer-reviewed journals.
• Research experience in oligodendrocyte biology, myelination, developmental neuroscience, or related neurobiology is highly desirable.
• Experience with human iPSC culture and differentiation, primary neural cell cultures, or advanced in vitro models is preferred.
• Experience with transcriptomic and translational profiling, single-cell RNA sequencing, or other OMICS approaches is advantageous.
• Experience with molecular biology techniques including qPCR, RNA analysis, immunocytochemistry/immunohistochemistry and fluorescence/confocal microscopy is advantageous.
• Experience with rodent models, tissue processing, and histological analyses is beneficial.
• Strong organizational, communication, and problem-solving skills with the ability to work independently and collaboratively in a multidisciplinary environment.
• Please include a CV and cover letter in your application.

The pay scale for this position is $65,000 to $87,000

NO PHONE CALLS PLEASE. PRINCIPALS ONLY.

Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

Equal Opportunity Employer
This employer is required to notify all applicants of their rights pursuant to federal employment laws.For further information, please review the Know Your Rights notice from the Department of Labor.