Postdoctoral Position, Gulick Lab, Buffalo, NY

Instruct-ERIC; Buffalo (NY); On-site; USD 60,000 - 75,000; Full time

Job summary

The State University of New York at Buffalo invites applications for a postdoctoral research associate in the Gulick Lab to study structural enzymology of bacterial natural product biosynthesis. The successful candidate will contribute to protein production, biochemical assay development, and structure determination using crystallography and cryo-EM.

Work spans informatics, genome mining, and data interpretation with opportunities for authorship and dissemination of results in high-profile

Qualifications

• PhD in Biochemistry, Chemistry, or related field.
• Background in protein biochemistry, enzymology, biophysical analysis, or structural biology.
• Ability to analyze, publish, and present research data.
• Self-motivation, ability to work independently and collaboratively as a team, with good time management.

Responsibilities

• Protein production, purification, and analysis, including development and implementation of biochemical assays.
• Informatic and genome mining to identify, characterize biosynthetic pathways.
• Protein structure determination through X-ray crystallography and/or cryo-EM and single particle analysis.
• Data analysis, maintenance, and interpretation, including contributions to publications and dissemination of research.

Skills

Protein biochemistry

Enzymology

Biophysical analysis

Structural biology

Data analysis

Publications/presentations

Education

PhD in Biochemistry, Chemistry, or related field

Tools

LC-MS

HPLC

X-ray crystallography

Cryo-EM

Computation tools

Job description

Jobs in Structural Biology and Related Fields

State University of New York(SUNY) at Buffalo, Buffalo, United States

A postdoctoral research associate position is available to work on an NIH-funded project in the lab of Prof. Andrew Gulick within the Department of Structural Biology, University at Buffalo.

The GulickLab investigates the structural enzymology of proteins involved in the biosynthesis of bacterial natural products. Through combinations of structural biology, biochemical characterization, protein engineering, and biocatalysis, we aim to explore the ability of bacteria to produce diverse small molecules to help them adapt to the challenges of surviving in diverse environments.

The postdoctoral associate will be responsible for:

• protein production, purification, and analysis, including development and implementation of biochemical assays
• informatic and genome mining to identify, characterize, and understand the diverse biosynthetic pathways of bacterial sources
• protein structure determination through X-ray crystallography and/or cryo-electron microscopy and single particle analysis
• data analysis, maintenance, and interpretation, including contributions on authoring publications and dissemination of research

Minimum Qualifications

• PhD in Biochemistry, Chemistry, or related field
• Background in protein biochemistry, enzymology, biophysical analysis, or structural biology
• Ability to analyze, publish, and present research data
• Self-motivation, ability to work both independently and collaboratively as a team. Ability to manage time and organization on multiple projects

Preferred Qualifications

• Interest in natural product biosynthesis, including pathway reconstitution, genetic manipulation, small molecule isolation and characterization
• Expertise in enzymology, including assay development, LC-MS and HPLC analysis
• Experience with X-ray crystallographic analysis and protein structure determination or single particle cryo-electron microscopy structure determination and analysis
• Familiarity with computation tools for protein structure determination and analysis.

Applications will be reviewed starting Oct 31 and will continue until filled.