Postdoctoral Fellow-MSH-32074-061

Mount Sinai; United States; On-site; USD 75,000 - 86,000; Full time

Job summary

Mount Sinai invites applications for a postdoctoral fellow in the Cardiovascular Research Institute to explore selective modified mRNA therapies for diabetic foot, skin ageing and cardiac regeneration.

The position focuses on in vitro screening, mRNA preparation, LNP formulation, in vivo studies in small/large animals, data analysis, and manuscript preparation, with the goal of advancing toward human clinical trials.

Qualifications

• PhD, MD, or MD/PhD required.
• Experience in regenerative medicine techniques.
• Expertise in cardiac repair, RNA biology or related fields.
• Strong analytical and manuscript preparation skills.

Responsibilities

• Conduct in vitro screening experiments.
• Prepare modified mRNA.
• Formulate and characterize lipid nanoparticles (LNPs).
• Analyze high-throughput datasets.
• Design, plan, and analyze in vivo studies in small and large animal models.
• Summarize research findings and prepare manuscripts for submission to peer‑reviewed journals.

Skills

Regenerative medicine techniques

RNA biology

Cardiac repair

Molecular biology

Immunology

Synthetic biology

Education

PhD, MD, or MD/PhD

Tools

LNP formulation

Job description

Salary: $74,692

Department: Cardiovascular Research Institute

Physical work location:

1470 Madison Ave,

Hess CSM 7th Floor, Room 301

New York, NY 10029

Name PI or Supervisor: Lior Zangi, [e-mail], 646-254-2800

Web link to Lab https://labs.icahn.mssm.edu/zangilab/?pk_vid=03a62fe621017b2517792149175db68d

Web link to Department: https://icahn.mssm.edu/research/cardiovascular

Administrative Contact: Christopher Chan; 212-824-9897; [e-mail]

Details of Research Project:

In this research project, the postdoctoral fellow will investigate the use of selective modified mRNA to treat different disease, such as diabetic foot, skin ageing and cardiac regeneration. Using murine and pig models, they will performed detailed activity and identify therapeutic genes that could promote regeneration and rejuvenations. Our studies are designed to advance toward human clinical trials and evaluate therapeutic value.

Technical Duties:

The candidate will be responsible for conducting in vitro screening experiments; preparing modified mRNA; formulating and characterizing lipid nanoparticles (LNPs); analyzing high-throughput datasets; designing, planning, and analyzing in vivo studies in small and large animal models; summarizing research findings; and preparing manuscripts for submission to peer-reviewed journals.

Educational and other Requirements for the position: PhD, MD, or MD/PhD

Experience Required: The qualified applicant should be skilled in regenerative medicine techniques and have at least one of the following additional areas of expertise: Cardiac repair, RNA biology, synthetic biology, heart failure, cardiology, immunology or molecular biology.

Goals/Outcomes of the Research Project:

Our goal is to identify new mRNA-based candidate genes that can prevent and treat diabetic foot, skin ageing and cardiac regeneration.

SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), J16 - Cardiovascular Research Institute - ISM, Icahn School of Medicine