Postdoctoral Fellow-MSH-32074-063

Mount Sinai Medical Center; New York (NY); On-site; USD 72,500 - 80,000; Full time

Job summary

Mount Sinai Health System in New York is seeking a PhD researcher to lead projects evaluating how the nervous system regulates macrophage function in the heart. You will perform mouse modeling, flow cytometry, and advanced imaging to study inflammatory processes in health and disease.

The role involves investigating neural control of cardiovascular inflammation and contributing to potential therapeutic approaches, with a focus on centralized research at the Cardiovascular Research Institute.

Qualifications

• Educational and other Requirements for the position: PhD

Responsibilities

• Responsibilities include evaluating neuronal control of macrophage function in the heart, and testing how neurotransmitters and neuropeptides modify macrophage subsets and inflammatory processes in the heart and vasculature.
• Technical duties include mouse modeling and handling, flow cytometry, advanced confocal imaging of the heart, single-cell sequencing, and neuronal manipulation methods such as neuronal ablation and brain circuit manipulation.
• Goals include identifying new signaling mechanisms by which the nervous system regulates inflammation in the cardiovascular system and developing therapies.

Education

PhD

Job description

Description

Salary: $74,692

Department: Cardiovascular Research Institute

Physical work location: 1470 Madison Ave, Hess Bldg, 7th Fl, New York, NY 10029

Name PI or Supervisor: Cameron McAlpine, 857-207-8093, [e-mail]

Web link to Lab: https://labs.icahn.mssm.edu/mcalpinelab/

Web link to Department: https://icahn.mssm.edu/research/cardiovascular

Administrative Contact: Mikaela Walcott, [e-mail], 212-824-8907

Responsibilities

Details of Research Project:

Title: Evaluate neuronal control of macrophage function in the heart.

The candidate will use fundamental science tools to test how the nervous system regulates macrophage function and biology in the heart. The candidate will test how neurotransmitters and neuropeptides modify macrophage subsets and inflammatory processes in the heart and its vasculature at steady state, after myocardial infarction, during atherosclerosis, or in the context of other cardiovascular pathologies.

Technical Duties: (include any protocols)

Technical duties will include mouse modeling and handling, flow cytometry, advance confocal imaging of the heart, single cell sequencing, and neuronal manipulation methods like neuronal ablation, neuropeptide deletion, and brain circuit manipulation. Molecular assays like protein quantification or mRNA expression.

Qualifications

Educational and other Requirements for the position: PhD

Experience Required: 0

Goals/Outcomes of the Research Project:

We will identify new ways by which the nervous system regulates inflammation in the cardiovascular system. Novel signaling mechanisms will be further developed and tested for therapeutic intervention.

J16 - Cardiovascular Research Institute - ISM, Icahn School of Medicine

Equal Opportunity Employer

The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.

Compensation

The Mount Sinai Health System provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.