Postdoctoral Fellow-MSH-32050-005

Mount Sinai; United States; On-site; USD 64,000 - 87,000; Full time

Job summary

The Blanchard Laboratories at the Icahn School of Medicine at Mount Sinai (ISMMS) in New York City are seeking exceptional Postdoctoral Scholars to join our team. This position focuses on industry-sponsored research validating AD risk variants in iPSC vascular cells and organoids.

As a member, you will differentiate iPSCs into vascular cells, develop brain organoids, and validate CRISPR-edited lines within organoid models, advancing understanding of Alzheimer’s disease mechanisms in a

Qualifications

• PhD in biology, biomedicine or related field completed.
• Experience differentiating iPSCs into vascular cells.
• Experience with brain organoids and CRISPR-edited lines.

Responsibilities

• Differentiate iPSCs into vascular cells.
• Develop and maintain brain organoids from iPSCs.
• Validate functionality of iPSC-derived vascular models in organoids.
• Co-culture iPSC-derived vascular cells with AD organoids.

Skills

iPSC differentiation

CRISPR editing

Organoid culture

Experiment design

Team collaboration

Education

PhD in biology/biomedicine

Tools

CRISPR/Cas9 toolkit

Stem cell culture equipment

Job description

Salary: $75,795

Department: Stem Cell Biology & Regenerative Medicine

Physical work location: 619 West 54th Street, 8th Floor.

Name PI or Supervisor: Dr. Joel Blanchard, [e-mail]

Web link to Lab: https://labs.neuroscience.mssm.edu/project/blanchard-lab/

Web link to Department: https://icahn.mssm.edu/about/departments/regenerative-biology

Administrative Contact: Nyomi Cepeda, [e-mail]

Details of Research Project:

The Blanchard Laboratories at the Icahn School of Medicine at Mount Sinai (ISMMS) in New York City is seeking exceptional Postdoctoral Scholars to join our team. This opportunity involves industry sponsored research in functional validation of Alzheimer’s disease (AD) associated risk variants in iPSC vascular cells and organoid. As a member of our team, you'll contribute to a groundbreaking project utilizing genetic engineering validation in iPSC-derived vascular models . You will be responsible for Differentiating iPSCs into vascular cells using established protocols, developing and maintaining brain organoids from iPSCs, designing experiments to validate the functionality and characteristics of iPSC-derived vascular moels (CRISPR-edited lines) within the organoid model. developing and optimizing protocols for co-culturing iPSC-derived vascular cells with AD organoids and perform functional validation experiments using established as well novel functional assays. We're looking for motivated researchers with strong collaborative skills and a passion for AD disease.

Technical Duties: Include Differentiating iPSCs into vascular cells using established protocols, developing and maintaining brain organoids from iPSCs, designing experiments to validate the functionality and characteristics of iPSC-derived vascular models (CRISPR-edited lines) within the organoid model.