Postdoctoral Scientist: Protein Mechanisms & Analytics

Amgen SA; Cambridge (MA); On-site; USD 65,000 - 90,000; Full time

Benefits offered by this job

Competitive benefits

Bonus program

Stock-based incentives

Flexible work model

Job summary

Amgen is seeking a Postdoctoral Fellow to generate mechanistic insights that influence analytical control strategies, molecule design, and formulation development across its biologics pipeline. You will design MS-based studies, identify degradation pathways, and translate findings into practical mitigation strategies while collaborating with a diverse team of scientists.

The role requires a PhD at appointment, expertise in mass spectrometry and protein chemistry, and a track record of

Qualifications

• PhD at time of appointment.
• Preferred: PhD in Analytical chemistry, physical chemistry, or related life sciences disciplines.
• Demonstrated independent design, execution, and interpretation of experiments with publications.

Responsibilities

• Design and execute MS-based mechanistic studies of protein fragmentation pathways in biologics.
• Identify fragmentation products and map fragmentation sites using MS, chromatography, and structural analysis.
• Integrate data with mechanistic modeling to predict degradation behavior.
• Translate findings into hypotheses and mitigation strategies for molecule design and storage.
• Publish findings in peer-reviewed journals and present at conferences.
• Collaborate within a large team of scientists across Amgen's pipeline.

Skills

Independent experimental design

Mass spectrometry

Chromatography

Protein chemistry

Communication skills

Education

PhD at appointment

Tools

ChemDraw

LC-MS/MS

High-resolution MS

Job description

Amgen is seeking a Postdoctoral Fellow to generate mechanistic insights that influence analytical control strategies, molecule design, and formulation development across its biologics pipeline. You will design MS-based studies, identify degradation pathways, and translate findings into practical mitigation strategies while collaborating with a diverse team of scientists.

The role requires a PhD at appointment, expertise in mass spectrometry and protein chemistry, and a track record of