Postdoctoral Fellow

BioSpace; Cambridge (MA); On-site; USD 85,000 - 110,000; Full time

Benefits offered by this job

Competitive benefits

Total Rewards Plan

Flexible work models

Job summary

Amgen seeks a Postdoctoral Fellow to generate mechanistic insights that influence analytical control strategy, molecule design, and formulation development across Amgen's pipeline.

You will design MS-based studies, apply advanced analytical techniques, and integrate data with modeling to improve degradation predictions, with opportunities to publish and present findings.

Qualifications

• PhD at time of appointment
• Demonstrated independent design and interpretation of experiments with publication record
• Strong understanding of protein chemistry and degradation pathways
• Experience with LC-MS/MS and high-resolution mass spectrometry

Responsibilities

• Design and execute MS-based mechanistic studies of protein fragmentation pathways
• Identify fragmentation products and map fragmentation sites
• Integrate data with modeling to predict degradation behavior
• Translate findings into hypotheses and mitigation strategies
• Publish findings in peer-reviewed journals and present at conferences

Skills

Analytical chemistry

Biomolecular chemistry

Mass spectrometry

LC-MS/MS

ChemDraw

Communication

Collaborative mindset

Education

PhD in Analytical chemistry or life sciences

Tools

ChemDraw

LC-MS/MS

Job description

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Postdoctoral Fellow

What You Will Do

Lets do this. Lets change the world. In this vital role you will generate mechanistic insights that directly influence analytical control strategy, molecule design, and formulation development across Amgen's pipeline.

• Design and execute MS-based mechanistic studies of protein fragmentation pathways in biologics, including stable-isotope solvent-labeling approaches such as DO and HO oxygen-incorporation experiments to distinguish hydrolytic, enzymatic, and chemical fragmentation mechanisms.
• Apply advanced analytical characterization techniques, including mass spectrometry, chromatography, and structural analysis, to identify fragmentation products, map fragmentation sites and characterize reaction intermediates.
• Integrate experimental data with mechanistic and statistical modeling to improve prediction of degradation behavior.
• Translate mechanistic findings into testable hypotheses and practical mitigation strategies, including molecule design (sequence selection), formulation considerations, and storage recommendations.
• Publish findings in high-impact peer-reviewed journals and contribute to intellectual property generation.
• Present research internally and externally at scientific conferences.

What We Expect Of You

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a leader with these qualifications.

Basic Qualifications

• PhD at time of appointment

Preferred Qualifications

• PhD at the time of appointment in Analytical chemistry, physical chemistry, or related life sciences disciplines
• Demonstration of independent design, execution, and interpretation of experiments and results, as exemplified by a solid publication record with first-author publication(s)
• Demonstrated expertise with ChemDraw and mechanistic biomolecular chemistry, including the ability to propose, illustrate, and evaluate reaction mechanisms relevant to protein and peptide degradation pathways. Strong understanding of protein chemistry, protein degradation pathways, peptide mapping, and biologics analytical characterization
• Experience with LC-MS/MS, high-resolution mass spectrometry and advanced protein characterization
• Excellent critical thinking, organizational, and communication skills
• Passion to learn and work collaboratively within a large team of scientists with diverse technical and cultural backgrounds

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In Addition To The Base Salary, Amgen Offers a Total Rewards Plan, Based On Eligibility, Comprising Of Health And Welfare Plans For Staff And Eligible Dependents, Financial Plans With Opportunities To Save Towards Retirement Or Other Goals, Work/life Balance, And Career Development Opportunities That May Include

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.