Postdoctoral Fellow: CNS-Targeted AAV Vector Development

Broad Institute of MIT and Harvard; Cambridge (MA); On-site; USD 70,000 - 93,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

Life insurance

Disability insurance

401(k) retirement plan

Flexible spending accounts

Health Savings Account

Paid holidays

Parental leave

Employee assistance program

Job summary

The Broad Institute of MIT and Harvard seeks a postdoctoral researcher or research scientist to join a multidisciplinary effort aimed at developing AAV vectors that enable targeted gene expression in disease-relevant CNS neuronal populations.

The role includes project planning, hands-on bench work, reporting results to leadership and collaborators, and contributing to scientific manuscripts and presentations within the Harvard/MIT ecosystem.

Qualifications

• Experience with molecular biology techniques
• NGS, high-throughput screening methods, immunohistochemistry/in situ hybridization
• Production of gene delivery vectors
• Hands-on stereotaxic injections
• Knowledge of bioinformatics and statistics
• Outstanding interpersonal and communication skills
• Demonstrated ability to work in a cross-disciplinary collaboration
• Excellent organizational and time management skills

Responsibilities

• Develop, refine and apply high-throughput selection methods to create novel capsids and gene expression systems
• Apply gene delivery strategies to multiple in vivo and in vitro models
• Use standard molecular biology techniques for plasmid construction, PCR, qPCR, RNA and DNA extraction and detection, and next generation sequencing (NGS)
• Conduct and/or supervise the production, purification and evaluation of AAV
• Troubleshoot problems and participate in evaluating and implementing new technologies
• Document, compile and analyze experimental data
• Attend and present at team meetings to share results and plan projects and experiments
• Contribute to scientific manuscripts, funding agency reports, and conference presentations
• Supervise the activities of one or more research associates
• Collaborate with team members to design, implement and troubleshoot critical experiments

Job description

The Broad Institute of MIT and Harvard seeks a postdoctoral researcher or research scientist to join a multidisciplinary effort aimed at developing AAV vectors that enable targeted gene expression in disease-relevant CNS neuronal populations.

The role includes project planning, hands-on bench work, reporting results to leadership and collaborators, and contributing to scientific manuscripts and presentations within the Harvard/MIT ecosystem.