Postdoctoral Associate - Deverman Lab

Broad Institute of MIT and Harvard; Cambridge (MA); On-site; USD 70,000 - 93,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

Life insurance

Disability insurance

401(k) retirement plan

Flexible spending accounts

Health Savings Account

Paid holidays

Parental leave

Employee assistance program

Job summary

The Broad Institute of MIT and Harvard seeks a postdoctoral researcher or research scientist to join a multidisciplinary effort aimed at developing AAV vectors that enable targeted gene expression in disease-relevant CNS neuronal populations.

The role includes project planning, hands-on bench work, reporting results to leadership and collaborators, and contributing to scientific manuscripts and presentations within the Harvard/MIT ecosystem.

Qualifications

• Experience with molecular biology techniques
• NGS, high-throughput screening methods, immunohistochemistry/in situ hybridization
• Production of gene delivery vectors
• Hands-on stereotaxic injections
• Knowledge of bioinformatics and statistics
• Outstanding interpersonal and communication skills
• Demonstrated ability to work in a cross-disciplinary collaboration
• Excellent organizational and time management skills

Responsibilities

• Develop, refine and apply high-throughput selection methods to create novel capsids and gene expression systems
• Apply gene delivery strategies to multiple in vivo and in vitro models
• Use standard molecular biology techniques for plasmid construction, PCR, qPCR, RNA and DNA extraction and detection, and next generation sequencing (NGS)
• Conduct and/or supervise the production, purification and evaluation of AAV
• Troubleshoot problems and participate in evaluating and implementing new technologies
• Document, compile and analyze experimental data
• Attend and present at team meetings to share results and plan projects and experiments
• Contribute to scientific manuscripts, funding agency reports, and conference presentations
• Supervise the activities of one or more research associates
• Collaborate with team members to design, implement and troubleshoot critical experiments

Job description

The Deverman lab at the Broad Institute of MIT & Harvard is looking for an exceptional and energetic postdoctoral researcher or research scientist to join a rapidly growing, multidisciplinary technology development research effort aimed at developing AAV vectors that enable targeted gene expression in a range of disease-relevant CNS neuronal populations.

We seek a candidate to join an exciting and funded project aimed at developing gene regulatory elements and custom AAV capsids that will enable modern genetically encoded tools to be specifically expressed within specific neuronal subclasses. This project is a collaboration between multiple laboratories at the Broad Institute. The role will include project planning, hands-on bench work, reporting results to leadership, collaborators, funding agencies, and contributing to scientific manuscripts and presentations. The successful candidate will be an employee of the Broad Institute and will have access to a wide array of internal career development opportunities and scientific talks throughout the wider Harvard/MIT research ecosystem.

CHARACTERISTIC DUTIES

• Develop, refine and apply novel high-throughput selection and screening methods to develop novel capsids and gene expression systems
• Apply gene delivery strategies to multiple in vivo and in vitro models
• Use standard molecular biology techniques for plasmid construction, PCR, qPCR, RNA and DNA extraction and detection, and next generation sequencing (NGS)
• Conduct and/or supervise the production, purification and evaluation of AAV
• Troubleshoot to resolve problems and participate in new technology evaluation, development and implementation
• Document, compile, and analyze experimental data
• Attend and present at team meetings to share results, plan projects and experiments
• Make significant contributions to scientific manuscripts, funding agency reports, and conference presentations
• Supervise the activities of one or more research associates
• Work closely with team members to design, implement and troubleshoot experiments critical to the group’s collective success

Qualifications

• 0-1+ years of related experience
• A PhD in a relevant discipline molecular or cell biology, neuroscience, or related disciplines
• Experience with molecular biology techniques
• Familiarity with NGS, high-throughput screening methods, immunohistochemistry/in situ hybridization, and production of gene delivery vectors is strongly desired
• Hands on experience with stereotaxic injections
• Knowledge of bioinformatics and statistics is helpful but not required
• Outstanding interpersonal and communication skills
• Demonstrated track record of, and continued interest in, working as part of a large cross-disciplinary collaboration in a fast-paced research environment
• Exceptional organizational and time management skills

Pay Range: $70,000.00/yr - $92,666.67/yr

The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law.

At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits.

The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations.

Should you need a reasonable accommodation to complete the application or interview process, please contact [e-mail] for assistance.