Postdoctoral Associate, Structural Biology Department

University at Buffalo; Buffalo (NY); On-site; USD 55,000 - 65,000; Full time

Job summary

The University at Buffalo is seeking a Postdoctoral Research Associate in the Gulick Lab within the Department of Structural Biology, Jacobs School of Medicine and Biomedical Sciences. The role focuses on bacterial natural product biosynthesis, combining structural biology, biochemistry, protein engineering, and biocatalysis to explore diverse small molecules produced by bacteria.

The successful candidate will produce and purify proteins, perform biochemical assays, conduct genome mining, and

Qualifications

• PhD in Biochemistry, Chemistry, or related field.
• Background in protein biochemistry, enzymology, biophysical analysis, or structural biology.
• Ability to analyze, publish, and present research data.
• Self-motivation and ability to work independently and collaboratively.

Responsibilities

• Protein production, purification, and analysis with biochemical assays.
• Informatic and genome mining to identify biosynthetic pathways.
• Protein structure determination via X-ray crystallography and/or cryo-EM.
• Data analysis, manuscripts, and dissemination of results.

Skills

Protein production

Protein purification

Biochemical assays

Genome mining

Biophysical analysis

Structural biology

Education

PhD in Biochemistry, Chemistry, or related field

Tools

X-ray crystallography

Cryo-EM

LC-MS

HPLC

Job description

A Postdoctoral Research Associate

position is available for an NIH -funded position in the lab of Prof. Andrew Gulick within the Department of Structural Biology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo.
The Gulick Lab investigates the structural enzymology of proteins involved in the biosynthesis of bacterial natural products. Through combinations of structural biology, biochemical characterization, protein engineering, and biocatalysis, we aim to explore the ability of bacteria to produce diverse small molecules that are produced to help them adapt to the challenges of surviving in diverse environments.

The postdoctoral associate will be responsible for:

• protein production, purification, and analysis, including development and implementation of biochemical assays
• informatic and genome mining to identify, characterize, and understand the diverse biosynthetic pathways of bacterial sources
• protein structure determination through X-ray crystallography and/or cryo-electron microscopy and single particle analysis
• Data analysis, maintenance, and interpretation, including contributions on authoring publications and dissemination of research

Learn more:

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The Research Foundation of SUNY is an EOE and welcomes all to apply including veterans and individuals with a disability.

Minimum Qualifications

• PhD in Biochemistry, Chemistry, or related field
• Background in protein biochemistry, enzymology, biophysical analysis, or structural biology
• Ability to analyze, publish, and present research data
• Self-motivation, ability to work both independently and collaboratively as a team. Ability to manage time and organization on multiple projects

Preferred Qualifications

• Interest in natural product biosynthesis, including pathway reconstitution, genetic manipulation, small molecule isolation and characterization
• Expertise in enzymology, including assay development, LC-MS and HPLC analysis
• Experience with X-ray crystallographic analysis and protein structure determination or single particle cryo-electron microscopy structure determination and analysis
• Familiarity with computation tools for protein structure determination and analysis.

Our University Community

Driving Requirements

Driving Requirements This position will never drive a university owned vehicle.

Salary Range

Salary Range $55,000 - $65,000

Work Hours

37.5 hours per week

Campus

Campus Downtown Campus

Supplemental Questions

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UB is an AA/EOE and welcomes all to apply including veterans and individuals with disabilities. Arrangements will be made if an applicant has a disability in order to provide access to the application, interview and selection process upon request. Reasonable accommodation requests must be made in a timely manner by email at [e-mail] or by phone [phone].