Postdoc: Stem Cell & Organoid Metabolism

Frederick National Laboratory for Cancer Research; Frederick (MD); On-site; USD 53,000 - 76,000; Full time

Job summary

Frederick National Laboratory for Cancer Research seeks a highly trained scientist to advance metabolic regulation in human stem cell fate using iPSC‑derived models. You will design reprogramming, differentiation, genome editing, and organoid culture systems for regenerative medicine.

The role emphasizes metabolic profiling, multi‑omics integration, and collaboration across NIH SOM Initiative; publish findings and contribute to collaborative grants.

Qualifications

• Possession of a doctorate degree from an accredited college or university according to the CHEA. Foreign degrees must be evaluated for U.S. equivalency.
• No work experience required with a Doctorate degree.
• Experience in mammalian cell culture and aseptic technique.
• Demonstrated experience designing and independently executing scientific research projects.
• Experience with molecular and cellular biology techniques.
• Evidence of scientific productivity through peer‑reviewed publications.
• Must possess basic Microsoft Office skills.
• Ability to obtain and maintain a security clearance.

Responsibilities

• Design and independently conduct innovative research investigating the metabolic regulation of human stem cell fate, lineage specification, differentiation, and tissue maturation using human iPSC‑derived models.
• Develop, optimize, and characterize human iPSC reprogramming, maintenance, genome editing, directed differentiation, and organoid culture systems for applications in regenerative medicine and disease modeling.
• Design and implement metabolic profiling approaches, including mitochondrial functional assays, extracellular flux analysis, metabolomics, stable isotope tracing, and complementary molecular and cellular approaches to define mechanisms regulating stem cell biology.
• Integrate transcriptomic, proteomic, metabolomic, imaging, and functional datasets to identify pathways governing stem cell fate and tissue maturation.
• Collaborate with multidisciplinary investigators across the NIH SOM Initiative to develop reproducible, scalable, and physiologically relevant stem cell and organoid platforms.
• Publish research findings in peer‑reviewed journals and present results at national and international scientific meetings.
• Contribute to grant applications, technical reports, manuscripts, and collaborative research initiatives.
• Contribute to the development and implementation of new experimental approaches and technologies that advance the mission of the Stem Cell Laboratory and the SOM Initiative.

Skills

Mammalian cell culture

Aseptic technique

Scientific research design

Molecular biology techniques

Peer‑reviewed publications

Security clearance readiness

Education

Doctorate degree (PhD)

Tools

Microsoft Office

Job description

Frederick National Laboratory for Cancer Research seeks a highly trained scientist to advance metabolic regulation in human stem cell fate using iPSC‑derived models. You will design reprogramming, differentiation, genome editing, and organoid culture systems for regenerative medicine.

The role emphasizes metabolic profiling, multi‑omics integration, and collaboration across NIH SOM Initiative; publish findings and contribute to collaborative grants.