Postdoc Scientist: Structural Biology & Drug Design

Mount Sinai Health System; New York (NY); On-site; USD 73,000 - 80,000; Full time

Job summary

Mount Sinai Health System in New York seeks a Postdoctoral Research Scientist in the Department of Genetics and Genomic Sciences to investigate the structure and function of disease‑related proteins using single‑particle cryo‑EM, X‑ray diffraction, and molecular simulations. You will collaborate with multidisciplinary teams to advance time‑resolved structural biology and structure‑based drug design.

Ideal candidates hold a recent PhD in structural biology or related fields, with hands-on

Qualifications

• Ph.D. in structural biology, biochemistry, biophysics, or related fields completed within the last three years.
• Proficiency in protein expression and purification in eukaryotic and prokaryotic systems.
• Experience in single-particle cryo-EM or crystallization, including structure determination and analysis of protein–ligand complexes.
• Ability to interact effectively with research staff at all levels and work within a multidisciplinary team.
• Good interpersonal, communication, and presentation skills.

Responsibilities

• Employ structural biology techniques to study disease‑related proteins and protein‑ligand complexes.
• Contribute to structure‑assisted drug design.
• Perform molecular dynamics simulations and QM/MM calculations.
• Publish research findings in peer‑reviewed journals and present results at conferences.
• Mentor graduate and undergraduate students.
• Contribute to grant proposals and progress reports.

Skills

Protein expression

Protein purification

Cryo-EM experience

X-ray crystallography

Interdisciplinary collaboration

Communication skills

Education

Ph.D. in structural biology/biochemistry/biophysics

Tools

Python programming

Biophysical characterization methods

Job description

Mount Sinai Health System in New York seeks a Postdoctoral Research Scientist in the Department of Genetics and Genomic Sciences to investigate the structure and function of disease‑related proteins using single‑particle cryo‑EM, X‑ray diffraction, and molecular simulations. You will collaborate with multidisciplinary teams to advance time‑resolved structural biology and structure‑based drug design.

Ideal candidates hold a recent PhD in structural biology or related fields, with hands-on