Postdoctoral Fellow-MSH-30001-321

Mount Sinai; New York (NY); On-site; USD 73,000 - 80,000; Full time

Job summary

Mount Sinai Health System in New York seeks a Postdoctoral Research Scientist in the Department of Genetics and Genomic Sciences to investigate the structure and function of disease‑related proteins using single‑particle cryo‑EM, X‑ray diffraction, and molecular simulations. You will collaborate with multidisciplinary teams to advance time‑resolved structural biology and structure‑based drug design.

Ideal candidates hold a recent PhD in structural biology or related fields, with hands-on

Qualifications

• Ph.D. in structural biology, biochemistry, biophysics, or related fields completed within the last three years.
• Proficiency in protein expression and purification in eukaryotic and prokaryotic systems.
• Experience in single-particle cryo-EM or crystallization, including structure determination and analysis of protein–ligand complexes.
• Ability to interact effectively with research staff at all levels and work within a multidisciplinary team.
• Good interpersonal, communication, and presentation skills.

Responsibilities

• Employ structural biology techniques to study disease‑related proteins and protein‑ligand complexes.
• Contribute to structure‑assisted drug design.
• Perform molecular dynamics simulations and QM/MM calculations.
• Publish research findings in peer‑reviewed journals and present results at conferences.
• Mentor graduate and undergraduate students.
• Contribute to grant proposals and progress reports.

Skills

Protein expression

Protein purification

Cryo-EM experience

X-ray crystallography

Interdisciplinary collaboration

Communication skills

Education

Ph.D. in structural biology/biochemistry/biophysics

Tools

Python programming

Biophysical characterization methods

Job description

Job Description

Postdoctoral Research Scientist Position

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai

Are you passionate about unraveling the mysteries of proteins and their roles in diseases like Alzheimer’s and cancer? Dr. Wei Wang (https://weiwanglab.com/) ’s lab at the Icahn School of Medicine at Mount Sinai is seeking motivated Postdoctoral Research Scientists to dive into groundbreaking structural biology research. Gain hands‑on experience with cutting‑edge techniques like cryo‑EM and X‑ray crystallography in a collaborative environment. This is an incredible opportunity for recent graduates to enhance their skills and contribute to high‑impact projects.

Please read following information about this opportunity to learn more.

Qualifications

Required Qualifications:

• Ph.D. in structural biology, biochemistry, biophysics, or related fields such as chemistry, physical chemistry, or biological structure research, completed within the last three years.
• Proficiency in protein expression and purification in eukaryotic and prokaryotic systems.
• Experience in single-particle cryo-EM or crystallization (or both), including structure determination and analysis of protein‑ligand complexes.
• Ability to interact effectively with research staff at all levels and work within a multidisciplinary team.
• Good interpersonal, communication, and presentation skills.

Preferred Qualifications:

• Experience and knowledge in structure‑based drug design.
• Proficiency in Python programming and its applications in structural biology.
• Experience with other biophysical characterization methods.
• A record of productive and creative research, demonstrated by publications in peer‑reviewed journals and presentations at scientific conferences.

Physical Requirements:

• Ability to perform experiments while seated or standing for extended periods.
• Dexterity to manipulate small laboratory tools and reagents.
• Occasionally involves light physical effort such as moving laboratory equipment or handling reagents.

Responsibilities

Position Summary:

As a Postdoctoral Research Scientist, you will contribute to the investigation of the structure and dynamics of disease‑related proteins using single-particle cryo‑EM, X‑ray diffraction, and molecular simulations. You will also participate in structure‑assisted drug design in collaboration with computational scientists. This role offers the opportunity to join a multidisciplinary team dedicated to advancing time‑resolved structural biology techniques to understand and manipulate the structure, function, and dynamics of drug targets.

Key Responsibilities:

• Employ structural biology techniques to study and understand the structure, function, and dynamics of disease‑related proteins and protein‑ligand complexes.
• Contribute to structure‑assisted drug design.
• Perform molecular dynamics simulations and QM/MM calculations.
• Publish research findings in peer‑reviewed journals and present results at national and international conferences.
• Mentor graduate and undergraduate students.
• Contribute to grant proposals and progress reports.

What We Offer:

• Comprehensive training in structural biology techniques such as cryo‑EM and protein crystallization.
• An opportunity to contribute to high‑impact research projects in the fields of neurodegenerative diseases and oncology.
• A supportive environment for skill development and career growth.
• Mentorship from senior lab members and access to state‑of‑the‑art research facilities.

About Us

Strength through Unity and Inclusion

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well‑being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.

About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high‑quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint‑venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report’s Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children’s Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

Equal Opportunity Employer

The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.

Compensation Statement

Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.