Postdoctoral Fellow-MSH-30001-321

Mount Sinai

United States

On-site

USD 55,000 - 70,000

Full time

14 days+

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Benefits offered by this job

Comprehensive training in structural biology techniques

Mentorship from senior lab members

Access to state-of-the-art research facilities

Job summary

A leading research institution is seeking a Postdoctoral Research Scientist to join a collaborative team focused on structural biology research. The position involves investigating disease-related proteins using cutting-edge techniques such as cryo-EM and X-ray crystallography. The ideal candidate will have a recent Ph.D. in structural biology or related fields and experience in protein expression and purification. This role provides opportunities for mentoring students and contributing to high-impact research projects, fostering skill development in a supportive environment.

Qualifications

Recent Ph.D. (completed within 3 years) in structural biology, biochemistry, or a related field.
Experience in single-particle cryo-EM or crystallization.
Ability to collaborate with multidisciplinary teams.

Responsibilities

Investigate structure and dynamics of disease-related proteins using cryo-EM and molecular simulations.
Participate in structure-assisted drug design.
Mentor graduate and undergraduate students.

Skills

Proficiency in protein expression and purification

Interpersonal and communication skills

Experience with cryo-EM or crystallization

Ability to work in teams

Education

Ph.D. in structural biology or related fields

Tools

Python programming

Job description

Postdoctoral Research Scientist Position

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai

Are you passionate about unraveling the mysteries of proteins and their roles in diseases like Alzheimer’s and cancer? Dr. Wei Wang’s lab at the Icahn School of Medicine at Mount Sinai is seeking motivated Postdoctoral Research Scientists to dive into groundbreaking structural biology research. Gain hands‑on experience with cutting‑edge techniques like cryo-EM and X‑ray crystallography in a collaborative environment. This is an incredible opportunity for recent graduates to enhance their skills and contribute to high‑impact projects.

Ready to make a difference? Apply now and be a part of our team!

Responsibilities

Position Summary:

As a Postdoctoral Research Scientist, you will contribute to the investigation of the structure and dynamics of disease‑related proteins using single‑particle cryo‑EM, X‑ray diffraction, and molecular simulations. You will also participate in structure‑assisted drug design in collaboration with computational scientists. This role offers the opportunity to join a multidisciplinary team dedicated to advancing time‑resolved structural biology techniques to understand and manipulate the structure, function, and dynamics of drug targets.

Key Responsibilities:

Employ structural biology techniques to study and understand the structure, function, and dynamics of disease‑related proteins and protein‑ligand complexes.
Contribute to structure‑assisted drug design.
Perform molecular dynamics simulations and QM/MM calculations.
Publish research findings in peer‑reviewed journals and present results at national and international conferences.
Mentor graduate and undergraduate students.
Contribute to grant proposals and progress reports.

What We Offer:

Comprehensive training in structural biology techniques such as cryo‑EM and protein crystallization.
An opportunity to contribute to high‑impact research projects in the fields of neurodegenerative diseases and oncology.
A supportive environment for skill development and career growth.
Mentorship from senior lab members and access to state‑of‑the‑art research facilities.

Qualifications

How to apply:

Please submit a single PDF containing your cover letter, curriculum vitae, and a list of publications when applying for this position. In your cover letter, briefly describe your research experience, career goals, and how your expertise aligns with this position. Additionally, include contact information for at least two references. Applications should be emailed to wei.wang@mssm.edu with your full name and the job position title in the subject line. Applications will be reviewed on a rolling basis, and selected candidates will be required to provide at least two confidential letters of reference.

Please read following information about this opportunity to learn more.

Required Qualifications:

Ph.D. in structural biology, biochemistry, biophysics, or related fields such as chemistry, physical chemistry, or biological structure research, completed within the last three years.
Proficiency in protein expression and purification in eukaryotic and prokaryotic systems.
Experience in single‑particle cryo‑EM or crystallization (or both), including structure determination and analysis of protein‑ligand complexes.
Ability to interact effectively with research staff at all levels and work within a multidisciplinary team.
Good interpersonal, communication, and presentation skills.

Preferred Qualifications:

Experience and knowledge in structure‑based drug design.
Proficiency in Python programming and its applications in structural biology.
Experience with other biophysical characterization methods.
A record of productive and creative research, demonstrated by publications in peer‑reviewed journals and presentations at scientific conferences.

Physical Requirements:

Ability to perform experiments while seated or standing for extended periods.
Dexterity to manipulate small laboratory tools and reagents.
Occasionally involves light physical effort such as moving laboratory equipment or handling reagents.

816 - Genetics/Genomic Sci - ISM, Icahn School of Medicine

About Us

Strength through Unity and Inclusion

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well‑being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.

About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high‑quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint‑venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report’s Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s "Best Children’s Hospitals" ranks Mount Sinai Kravis Children’s Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s "The World’s Best Smart Hospitals" ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

Equal Opportunity Employer

The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.

Job Info