Postdoc: Cryo-EM Structural Biology & Drug Discovery

St Jude Children's Research Hospital; Memphis (TN); On-site; USD 60,000 - 75,000; Full time

Benefits offered by this job

Competitive salary

Full benefits

Retirement contributions

Paid parental leave

Tuition reimbursement

Relocation support

Core facilities access

Computational resources

Professional development

Job summary

St. Jude Children's Research Hospital in Memphis invites applications for a highly motivated postdoctoral fellow to join the Sun lab in the Department of Structural Biology.

The role focuses on structure-based drug discovery using cryo-EM to understand small-molecule mechanisms. You will design and perform experiments in structural biology, biochemistry, and cell biology, express and purify proteins, collect cryo-EM data, and contribute to publications.

Qualifications

• Ph.D. in biochemistry, structural biology, biophysics, cell biology, pharmacology, chemical biology or related field.
• Ability to work independently and as part of a team.
• Strong publication record with at least one first-author paper.

Responsibilities

• Independently design, execute, troubleshoot, and interpret experiments in structural biology, biochemistry, and cell biology
• Perform protein complex expression/purification (mammalian and insect systems), cryo-EM sample preparation, data collection, and high-resolution structure determination to understand the working mechanism of small molecules
• Conduct functional assays in mammalian cells and animal models to study pharmacology of novel small molecules
• Rapidly learn and integrate new techniques as the project evolves
• Maintain detailed records, analyze data, prepare manuscripts, and present results at lab meetings and scientific conferences
• Work collaboratively with team members and external collaborators while taking ownership of sub-projects

Skills

Independent work

Team collaboration

Communication skills

Mentoring

Education

PhD in biochemistry/structural biology/biophysics

Tools

Cryo-EM

Protein expression/purification

Job description

St. Jude Children's Research Hospital in Memphis invites applications for a highly motivated postdoctoral fellow to join the Sun lab in the Department of Structural Biology.

The role focuses on structure-based drug discovery using cryo-EM to understand small-molecule mechanisms. You will design and perform experiments in structural biology, biochemistry, and cell biology, express and purify proteins, collect cryo-EM data, and contribute to publications.