Postdoctoral Scientist: Structural Biology & Cryo-EM Drug Discovery

St. Jude Children's Research Hospital, Inc.; Memphis (TN); Sur place; USD 52 000 - 75 000; Plein temps

Avantages offerts par ce poste

Competitive salary

Full benefits

Retirement contributions

Paid parental leave

Tuition reimbursement

Relocation support

Core facilities access

Unlimited computational resources

Professional development funding

Résumé du poste

St. Jude Children’s Research Hospital, Inc.

in Memphis invites applications for a postdoctoral fellow in the Sun Lab of the Department of Structural Biology to advance structure-based drug discovery using cryo-EM and related biochemical approaches. The role involves independently designing and executing experiments, protein expression/purification, cryo-EM data collection and analysis, and functional assays in cells and animal models, with opportunities to mentor junior team members and

Qualifications

• Ph.D. in biochemistry, structural biology, biophysics, cell biology, pharmacology, chemical biology or related field.
• Demonstrated ability to work independently and as part of a team.
• Strong publication record with at least one first-author paper in a peer-reviewed journal.

Responsabilités

• Independently design, execute, troubleshoot, and interpret experiments in structural biology, biochemistry, and cell biology.
• Perform protein complex expression/purification (mammalian and insect systems), cryo-EM sample preparation, data collection, and high-resolution structure determination to understand the working mechanism of small molecules.
• Conduct functional assays in mammalian cells and animal models to study pharmacology of novel small molecules.
• Rapidly learn and integrate new techniques as the project evolves.
• Maintain detailed records, analyze data, prepare manuscripts, and present results at lab meetings and scientific conferences.
• Work collaboratively with team members and external collaborators while taking ownership of sub-projects.

Connaissances

Publications

Teamwork

Communication skills

Mentoring

Formation

Ph.D. in biochemistry, structural biology, biophysics, cell biology, pharmacology, chemical biology or related field

Outils

Cryo-EM sample prep

Protein expression/purification

Description du poste

St. Jude Children’s Research Hospital, Inc.

in Memphis invites applications for a postdoctoral fellow in the Sun Lab of the Department of Structural Biology to advance structure-based drug discovery using cryo-EM and related biochemical approaches. The role involves independently designing and executing experiments, protein expression/purification, cryo-EM data collection and analysis, and functional assays in cells and animal models, with opportunities to mentor junior team members and