Post Doctoral Scholar - Physiology & Cell Biology

Wexner Medical Center; Columbus (OH); On-site; USD 48,000 - 62,000; Full time

Job summary

The Neginskaya Laboratory at The Ohio State University's Department of Physiology and Cell Biology invites applications for a Postdoctoral Scholar to study mitochondrial permeability transition and its role in ischemia-reperfusion injury in heart and brain.

The successful candidate will use interdisciplinary approaches including patch-clamp electrophysiology, live-cell imaging, cryo-EM/cryo-ET, and cross-linking mass spectrometry to advance mechanistic understanding and contribute to NIH-funded

Qualifications

• PhD in biochemistry, cell biology, biophysics, physiology, or related field.
• Strong publication record and ability to work independently and collaboratively.
• Excellent written and verbal communication skills.
• Experience in mitochondrial biology, membrane protein biochemistry, electrophysiology, or advanced imaging.

Responsibilities

• Plan, design, and execute experiments to investigate mitochondrial dysfunction in ischemia-reperfusion.
• Collect and analyze data for NIH and other funders.
• Develop and troubleshoot new experimental techniques and protocols.
• Present work at national and international conferences and contribute to manuscripts.

Skills

Independent research

Communication skills

Collaborative work

Education

PhD in biochemistry, cell biology, biophysics, physiology, or related field

Tools

Mitochondrial patch-clamp

Cryo-EM

Cryo-ET

Live-cell imaging

Cross-linking mass spectrometry

Biochemical & molecular approaches

Job description

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The Neginskaya Laboratory in the Department of Physiology and Cell Biology at The Ohio State University invites applications for a Postdoctoral Scholar position to investigate the molecular mechanisms of mitochondrial permeability transition. Mitochondrial permeability transition is a stress-induced increase in the permeability of the inner mitochondrial membrane that contributes to cell death and tissue injury in cardiovascular, neurological, and other diseases.

Current projects focus on the structural organization of mitochondrial membrane protein complexes under stress, the molecular mechanisms underlying mitochondrial permeability transition, and the signaling pathways that regulate mitochondrial dysfunction. The laboratory employs an interdisciplinary approach that integrates mitochondrial patch-clamp electrophysiology, advanced live-cell and label-free imaging, structural biology (cryo-electron tomography and cross-linking mass spectrometry), and biochemical and molecular approaches.

The laboratory employs an interdisciplinary approach that integrates mitochondrial patch-clamp electrophysiology, advanced live-cell and label-free imaging, structural biology (cryo-electron tomography and cross-linking mass spectrometry), and biochemical and molecular approaches.

The Postdoctoral Scholar will pursue specialized research training, education, and experience under the guidance of Dr. Neginskaya; plan, design, and execute experiments of considerable scope and complexity to investigate the mechanisms and role of mitochondrial dysfunction in ischemia-reperfusion injury in the heart and brain; collect and analyze data for research sponsored by the National Institutes of Health (NIH) and other funding agencies; identify and investigate significant research questions; develop and troubleshoot new experimental techniques and protocols; attend research seminars; contribute to manuscript preparation and scientific writing; and participate in the preparation of grant applications for extramural funding.

Minimum Education and Skills/Experience Required/Desired

A PhD in biochemistry, cell biology, biophysics, physiology, or a related field is required, along with a strong publication record, the ability to work independently and collaboratively, and excellent written and verbal communication skills. Candidates should have experience in one or more of the following areas: mitochondrial biology, membrane protein biochemistry, electrophysiology, live-cell microscopy, cryo-electron microscopy (cryo-EM) or cryo-electron tomography (cryo-ET), structural biology, quantitative image analysis, mouse models, or bioenergetics.

Our laboratory places a strong emphasis on scientific integrity, transparency, and ethical conduct. We seek team members who value honesty, take ownership of their work, and contribute to a supportive and respectful research environment.

The successful candidate will have the opportunity to develop independent research projects, learn unique experimental approaches, contribute to interdisciplinary studies of mitochondrial biology, and present their work at national and international scientific conferences.

Thank you for your interest in working at Ohio State.

Final candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post offer process.

The university is an equal opportunity employer, including veterans and disability.