Post Doctoral Fellow B - Vaccine Development and Global Health

University of Maryland, Baltimore; Baltimore (MD); Sur place; USD 52 000 - 78 000; Plein temps

Résumé du poste

The University of Maryland, Baltimore (UMB) Center for Vaccine Development and Global Health seeks a Postdoctoral Fellow to join Dr. Sztein’s Laboratory.

The Sztein Lab focuses on immunity to enteric fevers caused by Salmonella Typhi and Paratyphi and on developing multivalent vaccines to address rising antimicrobial resistance. The successful candidate will contribute to understanding CMI and innate immunity, employ systems biology and transcriptional analyses, and help translate findings into

Qualifications

• PhD in Immunology, Cell Biology, Pharmacology, Molecular Biology, or a related field.

Responsabilités

• Study immune responses to enteric fevers in humans and vaccine contexts.
• Investigate T- and B-cell mediated immunity and innate responses after immunization or exposure.
• Apply systems biology approaches to integrate epigenetics and scRNA-seq data.
• Identify immunological correlates of protection and publish findings.

Formation

PhD in Immunology, Cell Biology, Pharmacology, Molecular Biology, or a related field

Description du poste

Job Description

The University of Maryland, Baltimore (UMB), Center for Vaccine Development and Global Health (CVD) brings together more than four decades of innovative and life-saving research on vaccines and infectious diseases. http:// www.medschool.umaryland.edu/cvd/ As an organized research center within the University of Maryland School of Medicine (UMSOM), CVD comprises a multi-disciplinary team of faculty and staff whose primary mission is to develop, evaluate, and implement vaccines and other interventions to reduce illness and mortality domestically and in less developed countries. We work to prevent and treat enteric and respiratory diseases, to reduce the threat of malaria and antimicrobial resistance, and to identify, understand, and combat other tropic and emerging pathogens burdening low-resource settings. Training is a critical component of our work to ensure the foundation for the next generation of scientists and researchers committed to our mission.

The CVD is seeking a Post Doctoral Fellow to join Dr. Sztein’s Laboratory.

Responsibilities

The Sztein Lab is seeking a motivated Postdoctoral Fellow that has in depth study of immunity to enteric fevers caused by the human-restricted Salmonella enterica serovar Typhi (ST, typhoid fever) and serovar Paratyphi (SP, paratyphoid fever) which are major public health concerns. Given the growing antimicrobial resistance across the genus Salmonella, the generation of multivalent enteric fever vaccines are urgently needed. Thus, in depth studies of the immune response and which immune responses are associated with protection are urgently needed. Your studies will greatly extend major discoveries in Dr. Sztein’s laboratory during the past 3 decades in understanding T- and B-cell-mediated immunity (CMI) and innate immunity elicited by the licensed oral Ty21a and other candidate S. Typhi vaccines, as well as controlled human infection models. These studies will include system biology approaches to integrate epigenetics and sc-RNAseq transcriptional measurements and detailed immunological data (e.g., classical T-CMI, B-CMI and unconventional T cells immunity) following immunization or exposure to wild-type organisms with the ultimate goal of uncover key immunological responses associated with protection.

Qualifications

• PhD in Immunology, Cell Biology, Pharmacology, Molecular Biology, or a related field.
• Demonstrated experience of immune responses to infectious diseases and vaccines in different human populations including pregnant women, newborns, infants, and adults
• Strong experience with research focused on immune mechanisms that could prolong immunity from persistent infection via vaccination.

Preferred Experience

Candidates with experience in immune responses to infectious diseases and vaccines in different human populations including pregnant women, newborns, infants, and adults will be especially competitive.

About Us

The University of Maryland, Baltimore (UMB) is Maryland’s public health, law, and human services university. Six professional schools and the interdisciplinary Graduate School confer the majority of health care, human services, and law professional degrees in Maryland each year.

Our goal is to support the University’s mission of education, research, clinical care, and public service by amplifying UMB’s voice as a thought and action leader, and to enhance goodwill in the communities and people with whom we engage. UMB is a public university and constituent institution of the University System of Maryland. All employees are expected to work primarily physically within the State of Maryland.

UMB is committed to cultivating a diverse and inclusive workforce and is proud to be an equal employment opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, ancestry or national origin, sex, pregnancy or related conditions, sexual orientation, gender identity or expression, genetic information, physical or mental disability, marital status, protected veteran's status, or any other legally protected classification.

If you anticipate needing a reasonable accommodation for a disability under the Americans With Disabilities Act (ADA), during any part of the employment process, please submit a UMB Job Applicant Accommodation Request . You may also contact [e-mail]. Please note that only inquiries concerning an ADA request for reasonable accommodation will be responded to from this email address.

The University of Maryland, Baltimore prohibits sex discrimination in any education program or activity that it operates. Individuals may report concerns or questions to the Title IX Coordinator. Read the UMB Notice of Non-Discrimination for more information.

UMB is a public university and constituent institution of the University System of Maryland. All employees are expected to work primarily physically within the State of Maryland.

• Regular and contractual employee are eligible for a comprehensive benefits package

About the Team

The University of Maryland School of Medicine (SOM) was chartered in 1807 as the first public medical school in the United States. It continues today as one of the fastest growing, top-tier biomedical research enterprises in the world. SOM is dedicated to providing excellence in biomedical education, basic and clinical research, quality patient care and service to improve the health of the citizens of Maryland and beyond.