Post Doctoral Fellow B

University of Maryland, Baltimore; Baltimore (MD); Sur place; USD 48 000 - 60 000; Plein temps

Résumé du poste

The University of Maryland, Baltimore (UMB) Center for Vaccine Development and Global Health (CVD) invites applications for a Post Doctoral Fellow in the Sztein Lab. The successful candidate will investigate immune responses to enteric vaccines and contribute to translational vaccine research.

Responsibilities include mechanistic studies of T- and B-cell immunity, integration of sc-RNAseq data, and collaboration with multidisciplinary teams to advance vaccines against enteric pathogens.

Qualifications

• PhD in Immunology, Cell Biology, Pharmacology, Molecular Biology, or a related field.
• Demonstrated experience of immune responses to infectious diseases and vaccines in different human populations including pregnant women, newborns, infants, and adults
• Strong experience with research focused on immune mechanisms that could prolong immunity from persistent infection via vaccination.

Responsabilités

• Conduct in-depth studies of immune responses to enteric vaccines and related models.
• Apply system biology approaches to integrate epigenetics and scRNA-seq data with immunological readouts.
• Collaborate with multidisciplinary teams to identify key immunological correlates of protection.

Connaissances

Immunology

Cell Biology

Vaccinology

Formation

PhD in Immunology, Cell Biology, Pharmacology, Molecular Biology, or related field

Description du poste

Job Description

The University of Maryland, Baltimore (UMB), Center for VaccineDevelopment and Global Health (CVD) brings together more than fourdecades of innovative and life-saving research on vaccines andinfectious diseases. http://www.medschool.umaryland.edu/cvd/ As an organized researchcenter within the University of Maryland School of Medicine(UMSOM), CVD comprises a multi-disciplinary team of faculty andstaff whose primary mission is to develop, evaluate, and implementvaccines and other interventions to reduce illness and mortalitydomestically and in less developed countries. We work to preventand treat enteric and respiratory diseases, to reduce the threat ofmalaria and antimicrobial resistance, and to identify, understand,and combat other tropic and emerging pathogens burdeninglow-resource settings. Training is a critical component of our workto ensure the foundation for the next generation of scientists and researchers committed to our mission.

The CVD is seeking a Post Doctoral Fellow to join Dr. Sztein’sLaboratory.

Responsibilities

The Sztein Lab is seeking a motivated Postdoctoral Fellow that hasin depth study of immunity to enteric fevers caused by thehuman-restricted Salmonella enterica serovar Typhi (ST, typhoidfever) and serovar Paratyphi (SP, paratyphoid fever) which aremajor public health concerns. Given the growing antimicrobialresistance across the genus Salmonella, the generation ofmultivalent enteric fever vaccines are urgently needed. Thus, indepth studies of the immune response and which immune responses areassociated with protection are urgently needed. Your studies willgreatly extend major discoveries in Dr. Sztein’s laboratory duringthe past 3 decades in understanding T- and B-cell-mediated immunity(CMI) and innate immunity elicited by the licensed oral Ty21a andother candidate S. Typhi vaccines, as well as controlled humaninfection models. These studies will include system biologyapproaches to integrate epigenetics and sc-RNAseq transcriptionalmeasurements and detailed immunological data (e.g., classicalT-CMI, B-CMI and unconventional T cells immunity) followingimmunization or exposure to wild-type organisms with the ultimategoal of uncover key immunological responses associated withprotection.

Qualifications

Qualifications

• PhD in Immunology, Cell Biology, Pharmacology, MolecularBiology, or a related field.
• Demonstrated experience of immune responses to infectiousdiseases and vaccines in different human populations includingpregnant women, newborns, infants, and adults
• Strong experience with research focused on immune mechanismsthat could prolong immunity from persistent infection viavaccination.

Preferred Experience

Candidates with experience in immune responses to infectiousdiseases and vaccines in different human populations includingpregnant women, newborns, infants, and adults will be especiallycompetitive.

The ideal candidate will have strong communication andorganizational skills, scientific independence, and an interest indeveloping rigorous experimental systems.

About Us

The University of Maryland, Baltimore (UMB) is Maryland’s publichealth, law, and human services university. Six professionalschools and the interdisciplinary Graduate School confer themajority of health care, human services, and law professionaldegrees in Maryland each year.

Our goal is to support the University’s mission of education,research, clinical care, and public service by amplifying UMB’svoice as a thought and action leader, and to enhance goodwill inthe communities and people with whom we engage. UMB is a publicuniversity and constituent institution of the University System ofMaryland. All employees are expected to work primarily physicallywithin the State of Maryland.

UMB is committed to cultivating a diverse and inclusive workforceand is proud to be an equal employment opportunity employer. Allqualified applicants will receive consideration for employmentwithout regard to race, color, religion, age, ancestry or nationalorigin, sex, pregnancy or related conditions, sexual orientation,gender identity or expression, genetic information, physical ormental disability, marital status, protected veteran's status, orany other legally protected classification.

If you anticipate needing a reasonable accommodation for adisability under the Americans With Disabilities Act (ADA), duringany part of the employment process, please submit a UMB Job Applicant Accommodation Request . Youmay also contact [e-mail]. Please note that onlyinquiries concerning an ADA request for reasonable accommodationwill be responded to from this email address.

The University of Maryland, Baltimore prohibits sex discriminationin any education program or activity that it operates. Individualsmay report concerns or questions to the Title IX Coordinator. Readthe UMB Notice of Non-Discrimination for moreinformation.

UMB is a public university and constituent institution of theUniversity System of Maryland. All employees are expected to workprimarily physically within the State of Maryland. Regular and contractual employee are eligible for a comprehensive benefits package

About the Team

The University of Maryland School of Medicine (SOM) was charteredin 1807 as the first public medical school in the United States. Itcontinues today as one of the fastest growing, top-tier biomedicalresearch enterprises in the world. SOM is dedicated to providingexcellence in biomedical education, basic and clinical research,quality patient care and service to improve the health of thecitizens of Maryland and beyond.