PET Radioligand Development Scientist

UWMSN University of Wisconsin Madison; Wisconsin; On-site; USD 85,000 - 110,000; Full time

Job summary

The Nirschl and Kolb laboratories at the University of Wisconsin–Madison invite applications for a Scientist I or II to contribute to the discovery and development of novel PET imaging tracers targeting pathological protein aggregates in neurodegenerative diseases. The role emphasizes tissue-based assays, radioligand binding, and SPR to quantify molecular interactions in human and animal brain samples.

Candidates should have expertise in tissue assay development, protein biochemistry, or

Qualifications

• Experience in tissue-based assay development and protein biochemistry.
• Background in molecular imaging and radioligand techniques is a plus.
• Ability to work in a collaborative, interdisciplinary academic setting.

Responsibilities

• Lead discovery/optimization by setting up and executing tissue-based assays.
• Perform radioligand displacement and immunohistochemical validation.
• Conduct SPR experiments to quantify molecular interactions.
• Assist in SAR-driven lead optimization and biomarker validation.

Skills

Tissue-based assays

Biochemistry

Radioligand binding assays

Surface Plasmon Resonance (SPR)

Molecular imaging

SAR analysis

Tools

Autoradiography

SPR instrumentation

Immunoassays

Job description

The Nirschl and Kolb laboratories at the University of Wisconsin–Madison invite applications for a Scientist I or II to contribute to the discovery and development of novel PET imaging tracers targeting pathological protein aggregates in neurodegenerative diseases. The role emphasizes tissue-based assays, radioligand binding, and SPR to quantify molecular interactions in human and animal brain samples.

Candidates should have expertise in tissue assay development, protein biochemistry, or