Peptide & Oligonucleotide Process Development Scientist

PolyPeptide US; Torrance (CA); On-site; USD 90,000 - 115,000; Full time

Job summary

PolyPeptide US is seeking a Process Development Scientist to support the design, execution, optimization, and scale-up of synthetic processes for peptide and/or oligonucleotide API development at Torrance, CA. This role emphasizes hands-on process development, problem-solving, and collaboration with cross-functional teams to move projects from development into scalable, cGMP‑compliant manufacturing.

The successful candidate will develop robust, efficient, and cost-effective processes, contribute

Qualifications

• Ph.D. in Chemistry or related with 1+ year experience, or Master’s with 5+ years.
• Experience in organic chemistry and process development.
• Experience with peptide chemistry and downstream purification preferred.
• Ability to interpret analytical results and apply scientific judgment.
• Strong analytical thinking and problem solving.
• Work independently and with cross-functional teams.
• Strong communication and attention to detail.

Responsibilities

• Plan and coordinate technology transfer activities from Development to Production, onsite and across sites.
• Design, execute, and optimize synthetic processes for peptide and/or oligonucleotide API development.
• Perform intermediate chemical processing steps using established safety and process procedures.
• Check reactor systems for proper operation in accordance with SOPs and operating manuals.
• Monitor chemical reactions during processing and respond appropriately to ensure proper execution.
• Prepare solutions for purification.
• Interpret test results and take appropriate action to support acceptable processing.
• Purify crude peptide using HPLC under minimal supervision.
• Conduct lyophilization and drying processes according to established procedures.
• Perform in-process checks of fractions using analytical HPLC and report results to supervision or senior development personnel.
• Support troubleshooting of equipment and processing issues.
• Identify and report deviations, equipment concerns, or unresolved processing issues.
• Maintain high standards for safety, housekeeping, and cleanliness.
• Support cross-functional project teams with technical expertise.

Skills

Analytical thinking

Problem solving

Communication skills

Independent work

Education

Ph.D. in Chemistry or related

Master’s degree with 5+ years experience

Tools

HPLC purification

Analytical HPLC

Lyophilization

Drying processes

Technology transfer

Job description

PolyPeptide US is seeking a Process Development Scientist to support the design, execution, optimization, and scale-up of synthetic processes for peptide and/or oligonucleotide API development at Torrance, CA. This role emphasizes hands-on process development, problem-solving, and collaboration with cross-functional teams to move projects from development into scalable, cGMP‑compliant manufacturing.

The successful candidate will develop robust, efficient, and cost-effective processes, contribute