Peptide Process Scale-Up Engineer | GMP Manufacturing

PolyPeptide Laboratories B.V.; Torrance (CA); On-site; USD 85,000 - 105,000; Full time

Job summary

PolyPeptide is seeking a Development Scale-Up Engineer to bridge development and production for peptide manufacturing. You will scale up/down unit operations, work with chemists to meet process needs, and transfer processes from development to manufacturing in a GMP setting.

You will apply data analysis, DOE, and process modeling to improve yields, throughput, and costs, while supporting cost and capacity planning and automation opportunities.

Qualifications

• Master’s degree in Chemical Engineering or related field.
• Experience in process development, scale-up, scale-down, or manufacturing support.
• Experience in peptide manufacturing is highly beneficial.
• GMP-regulated environment experience preferred.

Responsibilities

• Scale up and scale down unit operations from lab to pilot and production scales.
• Collaborate with chemists to understand process requirements, challenges, and constraints.
• Support smooth transfer from Process Development to full-scale manufacturing.
• Apply data analysis, DOE, SPC to identify bottlenecks, reduce waste, and improve yields.
• Develop steady-state process simulation models to predict performance under varying conditions.
• Perform cost and capacity analyses to optimize production efficiency and material output.
• Support new product introductions and manufacturing transfer activities.
• Improve process capability, yield, throughput, cycle time, and manufacturing costs.
• Apply Lean Manufacturing, Six Sigma, DOE, SPC, and other continuous improvement tools.
• Identify opportunities for automation and increased efficiency.
• Ensure compliance with safety, quality, regulatory and company requirements.
• Report directly to the Head of Process Development.

Skills

Chemical engineering

Process optimization

Data analysis

Team collaboration

Problem solving

Education

Master's degree in Chemical Engineering

Tools

Peptide synthesis

Chromatography

Crystallization

Process modeling

DOE

SPC

Lean Six Sigma

Job description

PolyPeptide is seeking a Development Scale-Up Engineer to bridge development and production for peptide manufacturing. You will scale up/down unit operations, work with chemists to meet process needs, and transfer processes from development to manufacturing in a GMP setting.

You will apply data analysis, DOE, and process modeling to improve yields, throughput, and costs, while supporting cost and capacity planning and automation opportunities.