Process Development Chemist — Peptide Manufacturing (GMP)

PolyPeptide Laboratories B.V.; Torrance (CA); On-site; USD 41,000 - 48,000; Full time

Job summary

PolyPeptide is seeking a Process Development Chemist in Torrance, CA to lead hands-on peptide synthesis, purification, and drying operations within a GMP manufacturing setting. You will verify reactor readiness, prepare chemical ingredients precisely, and monitor progress to ensure high-quality production.

You will work independently and with a collaborative team, applying HPLC analysis and cGMP documentation to drive process improvements and timely delivery of products.

Qualifications

• Bachelor's degree in Chemistry or Chemical Engineering.
• 2+ years of professional experience in a pharmaceutical or biotechnology lab.
• Hands-on experience with HPLC systems.
• Working knowledge of cGMP environments and documentation.

Responsibilities

• Execute peptide synthesis, purification, and drying operations in accordance with SOPs and Batch Production Records (BPRs).
• Set up and verify reactor systems for proper operation.
• Measure, mix, and prepare chemical ingredients with accuracy and care.
• Monitor reaction progress and respond appropriately to ensure complete processing.
• Perform intermediate chemical processing steps under established safety and process guidelines.
• Prepare solutions for purification and purify crude peptides using HPLC.
• Conduct lyophilization and drying processes per validated procedures.
• Perform in-process analytical HPLC checks and communicate results to senior chemists.
• Make basic go/no-go processing decisions based on established criteria.
• Identify, report, and assist with troubleshooting equipment or process issues.
• Maintain high standards for safety, cleanliness, and GMP compliance.
• Support additional tasks as needed to meet production goals.

Skills

HPLC operation

Independent work

Detail-oriented

Technical writing

MS Office

Education

Bachelor's degree in Chemistry or Chemical Engineering

2+ years of pharma/biotech lab experience

Tools

HPLC systems

Job description

PolyPeptide is seeking a Process Development Chemist in Torrance, CA to lead hands-on peptide synthesis, purification, and drying operations within a GMP manufacturing setting. You will verify reactor readiness, prepare chemical ingredients precisely, and monitor progress to ensure high-quality production.

You will work independently and with a collaborative team, applying HPLC analysis and cGMP documentation to drive process improvements and timely delivery of products.