Organic Synthesis Chemist

Synergy; Dallas (TX); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Health Care Plan

Paid Time Off

Training & Development

Job summary

Synergy Bioscience is seeking an experienced organic chemist to lead enantiomeric synthesis projects in a collaborative lab setting. You will design and optimize multi-step syntheses, ensuring high yield and purity while maintaining rigorous documentation and compliance.

The role requires a Master’s or PhD in Organic Chemistry with 7+ years of hands-on experience. You will work closely with analytical teams, applying HPLC/GC-MS/LC-MS methods and chiral chromatography to support project timelines

Qualifications

• Master’s or PhD in Organic Chemistry required.
• 7+ years in organic synthesis of enantiomeric compounds.
• Experience with multi-step synthesis and route optimization.
• Strong knowledge of stereochemistry, enantiomeric synthesis and reaction mechanisms.
• GMP documentation experience in a lab environment.
• Ability to coordinate with analytical scientists on timelines.
• Experience with HPLC, GC-MS, LC-MS; chiral chromatography and NMR a plus.

Responsibilities

• Design and perform multi-step organic syntheses for enantiomeric entities.
• Develop and optimize synthetic routes for yield, purity, and scalability.
• Document procedures, data, and results in lab notebooks and reports.
• Collaborate with analytical scientists to support project goals and timelines.
• Ensure safety, GMP, and regulatory compliance in all activities.
• Troubleshoot synthesis challenges and propose innovative solutions.

Skills

Organic synthesis

Route optimization

Stereochemistry

GMP documentation

Analytical collaboration

HPLC/GC-MS/LC-MS

Chiral chromatography

NMR

Education

Master’s degree in Organic Chemistry

PhD in Organic Chemistry

Tools

HPLC

GC-MS

LC-MS

Chiral chromatography

NMR

Job description

Synergy Bioscience is a contract research, development, manufacturing, testing, and consulting organization serving pharmaceutical, biopharmaceutical, and medical device clients. The company supports product development through analytical, testing, and regulatory expertise, helping clients move complex programs forward with scientific rigor, quality, and precision.

In this role, you will contribute to chemistry programs focused on the development of enantiomeric chemical entities. This is an opportunity to apply deep organic synthesis expertise in a collaborative laboratory environment, working closely with cross-functional scientific partners to advance project goals while maintaining high standards for quality, documentation, and compliance.

Responsibilities

• Design and perform multi-step organic syntheses to produce enantiomeric chemical entities.
• Develop and optimize synthetic routes to improve yield, purity, and scalability of enantiomeric chemicals.
• Document experimental procedures, data, and results accurately in lab notebooks and reports, following good documentation practices.
• Collaborate with analytical scientists to support project goals and timeline.
• Ensure compliance with safety, GMP, and regulatory requirements in all laboratory activities.
• Troubleshoot synthetic scheme challenges, characterization data, and reaction conditions, and propose innovative solutions.

• Master’s degree or PhD in Organic Chemistry or a related field.
• 7+ years of hands-on experience in the organic synthesis of enantiomeric compounds.
• Experience with multi-step organic synthesis and route optimization.
• Deep knowledge of stereochemistry, enantiomeric synthesis, reaction mechanisms, synthetic methodologies, and analytical techniques.
• Hands-on experience documenting work in GMP-compliant laboratory environments.
• Experience working closely with analytical scientists, including interpreting characterization data, coordinating method support, and partnering on project timelines.
• Hands-on experience with HPLC, GC-MS, and LC-MS; experience with chiral chromatography and NMR is a plus.

• Health Care Plan (Medical, Dental & Vision)
• Paid Time Off (Vacation, Sick & Public Holidays)
• Training & Development