Organic Synthesis Chemist

Synergy Bioscience, Inc.; Dallas (TX); On-site; USD 90,000 - 130,000; Full time

Benefits offered by this job

Health Care Plan (Medical, Dental &amp

Paid Time Off (Vacation, Sick & PH

Training & Development

Job summary

Synergy Bioscience, Inc. seeks a senior organic chemist to lead enantiomeric synthesis programs. You will design multi-step routes, optimize yield and scalability, and document results in GMP-compliant lab notebooks.

The ideal candidate has a Master's or PhD in Organic Chemistry, 7+ years’ hands-on synthesis experience, and strong knowledge of stereochemistry, reaction mechanisms, and analytical techniques (HPLC, GC-MS, LC-MS).

Qualifications

• Master's or PhD in Organic Chemistry or related field.
• 7+ years of hands-on experience in the organic synthesis of enantiomeric compounds.
• Experience with multi-step organic synthesis and route optimization.
• Deep knowledge of stereochemistry, enantiomeric synthesis, reaction mechanisms, synthetic methodologies, and analytical techniques.
• Hands-on experience documenting work in GMP-compliant laboratory environments.
• Experience coordinating with analytical scientists and project timelines.
• Hands-on experience with HPLC, GC-MS, and LC-MS; chiral chromatography and NMR a plus.

Responsibilities

• Design and perform multi-step organic syntheses to produce enantiomeric chemical entities
• Develop and optimize synthetic routes to improve yield, purity, and scalability of enantiomeric chemicals
• Document experimental procedures, data, and results accurately in lab notebooks and reports, following good documentation practices
• Collaborate with analytical scientists to support project goals and timeline
• Ensure compliance with safety, GMP, and regulatory requirements in all laboratory activities
• Troubleshoot synthetic scheme challenges, characterization data, and reaction conditions, and propose innovative solutions

Skills

Enantiomeric synthesis

Stereochemistry

Synthesis optimization

GMP documentation

Analytical collaboration

Education

Master's or PhD in Organic Chemistry

Tools

HPLC

GC-MS

LC-MS

Chiral chromatography

NMR

Job description

Synergy Bioscience is a contract research, development, manufacturing, testing, and consulting organization serving pharmaceutical, biopharmaceutical, and medical device clients. The company supports product development through analytical, testing, and regulatory expertise, helping clients move complex programs forward with scientific rigor, quality, and precision.

In this role, you will contribute to chemistry programs focused on the development of enantiomeric chemical entities. This is an opportunity to apply deep organic synthesis expertise in a collaborative laboratory environment, working closely with cross-functional scientific partners to advance project goals while maintaining high standards for quality, documentation, and compliance.

Responsibilities

• Design and perform multi-step organic syntheses to produce enantiomeric chemical entities
• Develop and optimize synthetic routes to improve yield, purity, and scalability of enantiomeric chemicals
• Document experimental procedures, data, and results accurately in lab notebooks and reports, following good documentation practices
• Collaborate with analytical scientists to support project goals and timeline
• Ensure compliance with safety, GMP, and regulatory requirements in all laboratory activities
• Troubleshoot synthetic scheme challenges, characterization data, and reaction conditions, and propose innovative solutions

Requirements

• Master's degree or PhD in Organic Chemistry or a related field
• 7+ years of hands-on experience in the organic synthesis of enantiomeric compounds
• Experience with multi-step organic synthesis and route optimization
• Deep knowledge of stereochemistry, enantiomeric synthesis, reaction mechanisms, synthetic methodologies, and analytical techniques
• Hands-on experience documenting work in GMP-compliant laboratory environments
• Experience working closely with analytical scientists, including interpreting characterization data, coordinating method support, and partnering on project timelines
• Hands-on experience with HPLC, GC-MS, and LC-MS; experience with chiral chromatography and NMR is a plus

Benefits

• Health Care Plan (Medical, Dental & Vision)
• Paid Time Off (Vacation, Sick & Public Holidays)
• Training & Development