Onsite Discovery Biology Scientist — In Vivo & In Vitro

Soufflé Therapeutics; Watertown (MA); On-site; USD 90,000 - 130,000; Full time

Job summary

Soufflé Therapeutics in Watertown, MA seeks a Scientist in Discovery Biology to drive target discovery with in vivo and in vitro data. You will generate, analyze and present data shaping genetic medicine delivery, working with Discovery Biology, Protein, Discovery Technology and In Vivo teams.

You'll design pharmacology and PK/PD studies, isolate primary cells, and help validate new gene targets. This bench-focused role emphasizes meticulous records and clear scientific communication.

Qualifications

• PhD with 0+ years of experience; or MS with 8+ years or BS with 10+ years of relevant industry experience
• Hands-on experience with primary cell isolation from animal and human tissues, and sterile cell culture
• Experience with tissue preservation and processing for downstream analysis
• RNA isolation and downstream analysis (e.g., qPCR, ddPCR)
• Histochemistry and immunostaining (IF), in situ hybridization, microscopy and basic image analysis
• Self-driven, curious, collaborative and detail-oriented, with strong analytical and communication skills

Responsibilities

• Design and analyze in vitro and in vivo pharmacology and PK/PD studies
• Establish and execute methods for cell isolation from tissues
• Establish and validate pre-clinical disease models, both internally and with CRO partners
• Support validation of new gene targets
• Maintain accurate records of experimental procedures and protocols in compliance with electronic laboratory notebook standards

Skills

Cell isolation

Sterile cell culture

RNA isolation

qPCR/ddPCR

Histochemistry

Immunostaining

In situ hybridization

Microscopy

Image analysis

Analytical skills

Communication

Education

PhD

MS with 8+ years

BS with 10+ years

Tools

Laboratory techniques

Job description

Soufflé Therapeutics in Watertown, MA seeks a Scientist in Discovery Biology to drive target discovery with in vivo and in vitro data. You will generate, analyze and present data shaping genetic medicine delivery, working with Discovery Biology, Protein, Discovery Technology and In Vivo teams.

You'll design pharmacology and PK/PD studies, isolate primary cells, and help validate new gene targets. This bench-focused role emphasizes meticulous records and clear scientific communication.