Oligonucleotide Chemistry Research Associate

Novo Nordisk A/S; Boulder (CO); Hybrid; USD 77,000 - 97,000; Full time

Benefits offered by this job

Medical, dental, vision

401(k) plan

Tuition reimbursement

Paid time off

Job summary

Novo Nordisk seeks a Research Associate for Chemical Development in Boulder, CO. You will contribute to scalable syntheses, work-up, purifications and isolations of oligonucleotides, aiming to improve purity, yield and throughput in a manufacturing context.

The role emphasizes organic chemistry fundamentals, process development, tech transfer, and collaboration across Technical Operations. Strong writing and cross-functional teamwork are essential.

Qualifications

• BA/BS or Master's degree in Chemistry, Biology or related field with 0 years of industrial experience, or a High School Diploma with 8+ years relevant lab experience
• Ability to follow technical instructions with some independence
• Demonstratable laboratory skills in synthetic organic chemistry and/or oligonucleotide synthesis, characterization and purification
• Solid understanding of synthetic organic chemistry and/or oligonucleotide relevant reactions and mechanisms
• Detail-oriented in both data analysis and project timelines
• Self-motivated with a proactive mindset
• The successful candidate must possess excellent writing and communication skills and a demonstrated ability to work independently and with cross-functional teams
• Ability to thrive in a multi-disciplinary and fast-paced research environment with tight deadlines

Responsibilities

• Provide research and development support of current chemical development projects utilizing state of the art techniques for preparation and analysis of oligonucleotides or nucleic acids
• Conduct laboratory work in safe, clean, efficient manner that ensures a safe working environment for colleagues
• Characterize starting materials, intermediates and synthesized molecules using common analytical techniques such as HPLC, LCMS, NMR, GC, KF and UV-Vis
• Develop and optimize all elements of chemical transformations including reaction conditions, workup, purification and isolation. Ensure robustness and reproducibility of developed processes
• Work within Technical Operations team to optimize current manufacturing processes for key oligonucleotide intermediates and reagents for oligonucleotide synthesis
• Document and summarize results in laboratory notebook and written reports. Capable of drawing valid conclusions from concrete and abstract variables
• Contribute to the team’s knowledge through scientific literature review and discussions
• Maintain and troubleshoot common laboratory equipment
• Support development and authoring of research reports to provide to internal and external manufacturing teams
• Ability to complete assignments that meet clearly defined deadlines and time schedules

Skills

Organic chemistry

Oligonucleotide synthesis

Analytical techniques

Education

BA/BS in Chemistry or related field

Master's degree in Chemistry or related field

Tools

HPLC

LC-MS

NMR

UV-Vis

Job description

Novo Nordisk seeks a Research Associate for Chemical Development in Boulder, CO. You will contribute to scalable syntheses, work-up, purifications and isolations of oligonucleotides, aiming to improve purity, yield and throughput in a manufacturing context.

The role emphasizes organic chemistry fundamentals, process development, tech transfer, and collaboration across Technical Operations. Strong writing and cross-functional teamwork are essential.