Associate Scientist III, Oligonucleotide Process Development

Arrowhead Pharmaceuticals; Madison (WI); On-site; USD 85,000 - 120,000; Full time

Benefits offered by this job

Excellent benefit package

Job summary

Arrowhead Pharmaceuticals, Inc. in Madison, WI invites applications for an Associate Scientist III in the Process Development Chemistry Group, focusing on oligonucleotide analysis and synthesis development.

The role involves performing analytical techniques (HPLC, UV/Vis, LC-MS), data interpretation, and working with senior chemists to advance synthesis methods toward large-scale production, with documentation for Manufacturing transfer and strict data records.

Qualifications

• BS or MS in chemistry or biochemistry with an excellent understanding of organic and analytical chemistry.
• At least 4 years of experience working in a chemistry laboratory setting.
• Familiar with analytical instrumentation, test methodology/validations, data acquisition systems, and cGMP policies and practices.
• Ability to correctly analyze data/results and interpret outcome of experiments and propose appropriate follow-up.
• Excellent verbal and written communication skills
• Strong problem-solving skills
• Eagerness to learn new techniques
• Experience with small-molecule and macromolecule analytical techniques (e.g., HPLC, UV-Vis spectrophotometry, mass spectrometry, NMR, etc.)

Responsibilities

• Independently provide accurate analytical results in support of new and on-going projects with a focus on process characterization.
• Perform analytical techniques, such as HPLC, UV/Vis, LC/MS, etc.
• Handle, analyze and characterize chemicals, pharmaceuticals, and related organic molecules.
• Analyze data/results and interpret outcome of experiments and independently propose appropriate follow-up.
• Calibrate, maintain, and troubleshoot all analytical equipment.
• Work closely with senior chemists on development of new synthetic approaches to desired compounds with an eye toward large-scale synthesis.
• Cooperate with other chemists in the group in preparation of complex organic constructs
• Analyze small-molecule and macromolecular targets using standard methods
• Maintain a well-documented laboratory notebook
• Prepare documentation for transfer of new technologies to the Manufacturing group
• Track progress against project timelines, generate regular status updates, and communicate progress and issues to management, including presentation of findings at team meetings
• Coordinate delivery of materials both internally and externally

Skills

Communication skills

Problem solving

Data interpretation

Eagerness to learn

Data analysis

Education

BS or MS in chemistry/biochemistry

Tools

HPLC

LC-MS

NMR

UV-Vis

Job description

Arrowhead Pharmaceuticals, Inc. in Madison, WI invites applications for an Associate Scientist III in the Process Development Chemistry Group, focusing on oligonucleotide analysis and synthesis development.

The role involves performing analytical techniques (HPLC, UV/Vis, LC-MS), data interpretation, and working with senior chemists to advance synthesis methods toward large-scale production, with documentation for Manufacturing transfer and strict data records.