NGS & Single-Cell Sequencing Lab Specialist

Michigan Medicine; Ann Arbor (MI); Hybrid; USD 85,000 - 120,000; Full time

Benefits offered by this job

Excellent medical, dental and vision

2:1 Match on retirement savings

Job summary

Michigan Medicine is expanding the Michigan Center for Translational Pathology laboratory to advance cancer research through high-throughput sequencing technologies, including RNA-Seq, single-cell and spatial transcriptomics. Join a collaborative team using Xenium and CytoAssist platforms to develop prognostic biomarkers and learn leading cellular/molecular techniques.

The role requires a Master’s in biology and at least five years of lab experience, with skills in qPCR, cloning, cell culture

Qualifications

• Master's degree required with ≥5 years in basic lab research.
• Experience in molecular biology and biochemistry labs.
• Familiar with qPCR, molecular cloning and cell culture.
• Experience with NGS library preparation (RNA-Seq, ChIP-Seq, Capture-Seq, etc.).
• Willingness to learn single-cell/spatial transcriptomics platforms; cross-project collaboration.

Responsibilities

• Isolate RNA and DNA from tissues and blood and prepare samples for sequencing.
• Check sample quality via spectrophotometer, bioanalyzer, and qPCR.
• Prepare NGS libraries for the lab and collaborators.
• Support library prep for single-cell and spatial transcriptomics libraries.
• Run next-generation sequencing platforms and validate genes with Sanger/qPCR.
• Write internal research reports and participate in group meetings.
• Maintain documentation for lab inspections and SOPs.
• Run instrument validations and optimize new technologies.

Skills

qPCR techniques

Molecular cloning

Cell culture

NGS library prep

Single cell / spatial transcriptomics

Team collaboration

Education

Master's degree in biology or related field

PhD in biological sciences (desired)

Tools

Xenium

CytoAssist

Bioanalyzer

Spectrophotometer

qPCR instrument

Job description

Michigan Medicine is expanding the Michigan Center for Translational Pathology laboratory to advance cancer research through high-throughput sequencing technologies, including RNA-Seq, single-cell and spatial transcriptomics. Join a collaborative team using Xenium and CytoAssist platforms to develop prognostic biomarkers and learn leading cellular/molecular techniques.

The role requires a Master’s in biology and at least five years of lab experience, with skills in qPCR, cloning, cell culture