Research Scientist II – Analytical Genomics Laboratory

Scorpion Therapeutics; Cambridge (MA); On-site; USD 95,000 - 130,000; Full time

Job summary

Scorpion Therapeutics in Cambridge, MA is seeking a biology-focused researcher to advance single-cell and spatial genomics workflows. You will perform experiments, prepare samples, and construct sequencing libraries within a cross-functional team.

Strong molecular biology skills and hands-on experience with spatial transcriptomics or single-cell sequencing are required. You will document results, troubleshoot protocols, and contribute to internal reports and presentations.

Qualifications

• MS or BS with relevant biology degree and equivalent experience.
• Hands-on experience with spatial transcriptomics and/or single-cell sequencing.
• Knowledge of molecular biology techniques including PCR, qRT-PCR, DNA/RNA purification.
• Experience troubleshooting protocols (with guidance) for complex genomics assays.
• Knowledge of NGS library preparation and sequencing workflows.

Responsibilities

• Perform experiments using established single-cell and spatial profiling workflows.
• Execute sample preparation, library construction, and sequencing-related protocols per SOPs and study plans.
• Provide input on sample requirements, workflow feasibility, timing, and run setup (under guidance).
• Support troubleshooting and implement approved protocol adjustments; escape technical issues as appropriate.
• Ensure accurate documentation and reproducibility.
• Operate and maintain relevant instruments (routine care and basic troubleshooting).
• Support training of other staff on instrument use and protocol adherence.
• Perform initial data processing for spatial and single-cell genomics datasets using appropriate bioinformatics tools.
• Collaborate with data scientists; contribute to reports and internal presentations.
• Work with local and remote cross-functional teams; communicate experimental status and technical observations.
• Document work accurately; monitor QC measures to ensure data integrity and compliance with lab standards.
• Stay current with advances in single-cell/spatial genomics and help integrate best practices into lab workflows.

Skills

Single-cell sequencing

Spatial transcriptomics

PCR

qRT-PCR

DNA/RNA purification

Education

MS in Molecular Biology

BS + 2 years experience

Tools

NGS library prep

Sequencing workflows

Job description

Key Responsibilities

• Perform experiments using established single-cell and spatial profiling workflows.
• Execute sample preparation, library construction, and sequencing-related protocols per SOPs and study plans.
• Provide input on sample requirements, workflow feasibility, timing, and run setup (under guidance).
• Support troubleshooting and implement approved protocol adjustments; escape technical issues as appropriate.
• Ensure accurate documentation and reproducibility.
• Operate and maintain relevant instruments (routine care and basic troubleshooting).
• Support training of other staff on instrument use and protocol adherence.
• Perform initial data processing for spatial and single-cell genomics datasets using appropriate bioinformatics tools.
• Collaborate with data scientists; contribute to reports and internal presentations.
• Work with local and remote cross-functional teams; communicate experimental status and technical observations.
• Document work accurately; monitor QC measures to ensure data integrity and compliance with lab standards.
• Stay current with advances in single-cell/spatial genomics and help integrate best practices into lab workflows.

Essential Requirements

• MS (or BS + 2 years experience) in Molecular Biology, Genomics, Biochemistry, or related field (or equivalent experience).
• 1–2 years hands-on experience with spatial transcriptomics and/or single-cell sequencing.
• Knowledge of molecular biology techniques including PCR, qRT-PCR, enzymatic reactions, DNA/RNA purification and manipulation.
• Experience troubleshooting and optimizing protocols (with guidance) for complex genomics assays.
• Knowledge of NGS library preparation and sequencing workflows.

Desirable Requirements

• Experience with tissue processing, imaging, IHC, and microscopy.