mRNA Process Development Scientist - Scale-Up & Purification

elevatebio; Waltham (MA); On-site; USD 105,000 - 145,000; Full time

Job summary

ElevateBio is seeking a highly skilled mRNA Scientist to join our process development team. The ideal candidate will design, execute, and optimize experiments related to mRNA production and purification, supporting tech transfer of mRNA-based therapeutics.

You will lead development and scale-up, characterize samples, collaborate across teams, help create SOWs, communicate results, and contribute to SOPs for regulatory-ready processes.

Qualifications

• BS/MS in Microbiology, Biochemistry, or related field with 8+ years experience, 4+ years in mRNA therapeutics.
• Hands-on IVT, plasmid DNA linearization, and downstream mRNA methods.
• Experience with GMP concepts and tech transfer activities.

Responsibilities

• Lead development, optimization, and scale-up of mRNA processes for yields and purity.
• Characterize mRNA samples via electrophoresis, spectroscopy, HPLC/UPLC.
• Collaborate with MSAT, analytical development, and external clients to support projects.
• Assist in creating SOWs and proposals for external partnerships.
• Communicate results to internal and external stakeholders; contribute to SOPs.

Skills

mRNA synthesis

mRNA purification

mRNA characterization

IVT

TFF

Chromatography

Tech transfer

DoE JMP

Education

BS/MS in Microbiology, Biochemistry, Bioengineering

Tools

ÄKTA Avant/Pure

Repligen KrosFlow Kr2i

HPLC/UPLC

Job description

ElevateBio is seeking a highly skilled mRNA Scientist to join our process development team. The ideal candidate will design, execute, and optimize experiments related to mRNA production and purification, supporting tech transfer of mRNA-based therapeutics.

You will lead development and scale-up, characterize samples, collaborate across teams, help create SOWs, communicate results, and contribute to SOPs for regulatory-ready processes.