mRNA Downstream Purification Scientist—Scale & Transfer

NewLimit; South San Francisco (CA); On-site; USD 120,000 - 155,000; Full time

Benefits offered by this job

Health, dental, and vision insurance

401(k) with company match

Paid parental leave

20 days PTO + holidays

Meals and snacks on-site

Job summary

NewLimit, a biotechnology company in South San Francisco, seeks a Scientist to lead downstream process development for the mRNA Engineering team. You will design, optimize, and scale purification processes for mRNA drug substance, spanning program process development and platform engineering.

The candidate will implement automated downstream workflows for high‑throughput purification, support bench-to-pilot scale manufacturing, and contribute to CDMO tech transfer with thorough data

Qualifications

• Ph.D. in analytical chemistry, biochemistry, molecular biology, chemical engineering, or a related field with 0–3 years of relevant industry experience, or an M.S. with 5+ years or B.S. with 7+ years of relevant industry experience
• Hands-on experience developing downstream purification processes for nucleic acids or other biologics
• Hands-on experience with tangential flow filtration (TFF)
• Experience operating ÄKTA chromatography systems
• Ability to independently design, execute, and troubleshoot experiments
• Ability to analyze and present complex data sets
• Strong technical writing skills
• Excellent communication and organizational skills

Responsibilities

• Design, execute, and analyze process development studies for mRNA purification
• Act as the downstream lead for CMC program teams
• Help design and implement automated downstream workflows for high‑throughput purification of research‑grade mRNA
• Support execution of research‑grade mRNA production runs for discovery and preclinical studies, as needed
• Support process scale‑up from bench to pilot scale, as needed
• Evaluate emerging purification technologies and chromatography resins
• Perform tech transfer of downstream processes to CDMOs
• Act as person in plant during CDMO manufacturing runs
• Support process troubleshooting and deviation investigations at CDMOs
• Maintain organized experimental records in Electronic Lab Notebooks
• Author development SOPs and technical development reports
• Present experiment results at team meetings

Skills

Downstream purification

TFF

ÄKTA chromatography

Data analysis

Technical writing

Communication

Organization

Education

Ph.D. in analytical chemistry / related field

M.S. with 5+ years / B.S. with 7+ years industry experience

Tools

ÄKTA chromatography systems

Job description

NewLimit, a biotechnology company in South San Francisco, seeks a Scientist to lead downstream process development for the mRNA Engineering team. You will design, optimize, and scale purification processes for mRNA drug substance, spanning program process development and platform engineering.

The candidate will implement automated downstream workflows for high‑throughput purification, support bench-to-pilot scale manufacturing, and contribute to CDMO tech transfer with thorough data