Senior mRNA Process Engineer — Build & Optimize

NewLimit; South San Francisco (CA); On-site; USD 75,000 - 100,000; Full time

Benefits offered by this job

Health insurance

Dental insurance

Vision insurance

401(k) match

Parental leave

PTO 20 days

Job summary

NewLimit is seeking a Senior/Research Associate to generate research-grade mRNA and support the mRNA Engineering team in a fast-paced lab environment. The role involves executing IVT workflows, purification, and detailed record-keeping, with collaboration across research and Delivery Sciences teams.

Early-career scientists gain hands-on training and contribute to impactful projects within aging biology. You will perform DNA template prep, IVT, purification, and analytical checks, while

Qualifications

• B.S. in Life Sciences, Chemistry, Engineering, or a related field with 1–2 years of relevant full-time industry or academic research experience, or M.S. in Life Sciences
• Hands-on experience with molecular biology techniques such as cloning, nucleic acid purification, PCR, and gel electrophoresis
• Strong attention to detail and good documentation practices
• Ability to execute protocols accurately and manage multiple tasks efficiently
• Excellent communication and organizational skills
• Interest in mRNA process science and eagerness to learn new techniques

Responsibilities

• Generate research-grade mRNA via DNA template preparation, in vitro transcription, and downstream purification
• Run routine analytical assays to assess mRNA integrity and purity
• Troubleshoot production issues and contribute to experiments that optimize yield, purity, and recovery
• Maintain detailed records in Electronic Lab Notebooks and follow SOPs
• Manage raw material and mRNA inventory, including sample tracking and reagent ordering
• Coordinate material needs and hand off mRNA for downstream studies
• Present experiment results at team meetings

Skills

Molecular biology techniques

Documentation & records

Multitasking & organization

Communication skills

Education

BS in Life Sciences / related field

MS in Life Sciences

Tools

PCR

Gel electrophoresis

HPLC

UV-Vis

TapeStation

Job description

NewLimit is seeking a Senior/Research Associate to generate research-grade mRNA and support the mRNA Engineering team in a fast-paced lab environment. The role involves executing IVT workflows, purification, and detailed record-keeping, with collaboration across research and Delivery Sciences teams.

Early-career scientists gain hands-on training and contribute to impactful projects within aging biology. You will perform DNA template prep, IVT, purification, and analytical checks, while