Senior mRNA Downstream Process Engineer

CRISPR Therapeutics; Boston (MA); On-site; USD 97,000 - 108,000; Full time

Job summary

CRISPR Therapeutics, based in Boston, seeks an Engineer III to own downstream process development for mRNA drug substance and to carry those processes into GMP production at external CDMOs. You will design, develop, and scale the purification process from bench through pilot scale in-house, then facilitate the technical transfer, engineering runs, and GMP campaign support at partner sites.

The role is engineering-forward and externally facing; requires a BS or MS in a related field with 4–6+

Qualifications

• BS or MS in a technical engineering field with relevant industry experience.
• Hands-on downstream process development for biologics or nucleic acids.
• Experience scaling processes from bench to pilot and transferring to CDMOs.
• Familiarity with chromatography, TFF, DoE, and statistical tools such as JMP or Design-Expert.

Responsibilities

• Own downstream process development for mRNA drug substance.
• Scale purification from bench through pilot scale and support GMP campaigns.
• Lead technology transfer to CDMOs and review partner documentation.
• Collaborate cross-functionally to align with analytical, formulation, and supply chain teams.

Skills

Downstream process development

Scale-up experience

DoE & statistical analysis

Transfer to external manufacturers

Strong communication

Education

BS in Chemical Engineering, Biochemical Engineering, Bioengineering, or related field

MS in Chemical Engineering, Biochemical Engineering, Bioengineering, or related field

Tools

JMP

Design-Expert

Job description

CRISPR Therapeutics, based in Boston, seeks an Engineer III to own downstream process development for mRNA drug substance and to carry those processes into GMP production at external CDMOs. You will design, develop, and scale the purification process from bench through pilot scale in-house, then facilitate the technical transfer, engineering runs, and GMP campaign support at partner sites.

The role is engineering-forward and externally facing; requires a BS or MS in a related field with 4–6+