Mixed Modality (Oligonucleotide) Scientist

Scorpion Therapeutics; Indianapolis (IN); On-site; USD 140,000 - 190,000; Full time

Job summary

Lilly's Medicine Foundry in Indianapolis seeks a Principal Scientist specializing in oligonucleotide process transfer and scale-up to deliver clinical supply readiness for early-phase trials.

You will oversee transfer from development to manufacturing, troubleshoot issues, scale-up methods, author technical docs, lead process improvements, and mentor junior staff while working in Indianapolis and Lebanon, IN with travel under 5%.

Qualifications

• Bachelor's or Master's degree in Chemistry or Biochemistry or related field.
• 7+ years (MS) or 10+ years (BS) of oligonucleotide process development or manufacturing.
• Expertise in oligo synthesis, chromatography, TFF, and lyophilization.
• Strong data analysis and scientific troubleshooting skills.
• Experience in GMP-regulated environments.

Responsibilities

• Oversee transfer from development to manufacturing and troubleshoot production issues.
• Evaluate and scale-up synthesis and purification methods.
• Author technical documentation and lead process improvements.
• Support investigations and deviations.
• Mentor junior staff.

Skills

Oligonucleotide synthesis

Chromatography

TFF

Lyophilization

Data analysis

GMP experience

Process development

Education

Bachelor's degree in Chemistry/Biochemistry

Master's degree in Chemistry/Biochemistry

Tools

HPLC/UPLC

LC-MS

TFF equipment

Lyophilization equipment

Job description

Role

Principal Scientist specializing in oligonucleotide process transfer and scale-up within Lilly's new Medicine Foundry, focusing on delivering clinical supply readiness for early-phase trials.

Responsibilities

• oversee process transfer from development to manufacturing, troubleshoot production issues, evaluate and scale-up synthesis/purification methods, author technical documentation, lead process improvements, and support investigations and deviations; mentor junior staff.

Requirements

• B.S. or M.S. in Chemistry, Biochemistry, or related;
• 7+ years (M.S.) or 10+ years (B.S.) experience in oligonucleotide process development or manufacturing;
• expertise in oligo synthesis, chromatography, TFF, lyophilization;
• strong data analysis and scientific troubleshooting skills;
• experience working with GMP regulated environments.

Preferred

• knowledge of upstream/downstream oligonucleotide processing, advanced analytical techniques (HPLC/UPLC, LC-MS), and process chemistry concepts;
• prior supervisory experience.

High-Value

• focus on synthetic molecules and biologics, early-stage clinical manufacturing, process transfer, and cGMP compliance.

Location

initial at Indianapolis, permanent at Lebanon, Indiana; <5% travel; work in manufacturing/lab settings.