Scientific Director, Process Chemistry - Oligonucleotides

Eli Lilly and Company; Indianapolis (IN); On-site; USD 149,000 - 257,000; Full time

Benefits offered by this job

Company bonus

401(k)

Vacation benefits

Career development

Job summary

Eli Lilly and Company is seeking an experienced scientist to advance oligonucleotide CMC development within the SMDD organization at Lilly’s Indianapolis site. You will develop and transfer synthesis processes, collaborate across teams, and address regulatory questions for clinical trials and commercialization.

The role emphasizes leadership, novel chemistry development, and partnership with internal/CMO manufacturing to enable scalable, environmentally conscious production of oligonucleotide

Qualifications

• PhD with 5+ years' industry experience in synthesis, oligonucleotides, solid-phase synthesis, CMC.
• MS with 8+ years' industry experience in synthesis, oligonucleotides, solid-phase synthesis, CMC.
• Experience in pharmaceutical sector: active ingredient development and formulated products; from mid-development to commercialization.
• Experience with tech transfer of processes into manufacturing operations.

Responsibilities

• Bring extensive oligonucleotide CMC expertise to SMDD and coach and lead across a diverse portfolio.
• Apply modern organic and nucleic acid chemistry to challenge methods and enable new technologies.
• Develop impurity control strategies aligned with global regulatory climate for clinical studies and regulatory submissions.
• Provide technical leadership across route design, process development, and scale-up with internal and external manufacturing partners.
• Demonstrate skills with automated reactor platforms and purification technologies across the portfolio.
• Collaborate with internal CMC networks to deliver materials and documentation for trials and submissions.
• Identify external chemistry innovations to complement internal capabilities and represent Lilly externally.
• Contribute to novel chemical design and problem solving, with publications in peer-reviewed journals.
• Lead through ambiguity and drive accountability and diverse perspectives.

Skills

Oligonucleotide synthesis

CMC

Process development

Leadership

Cross-functional collaboration

Education

PhD in Chemistry / related field

MS in Chemistry / related field

Job description

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Overview

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

Organization And Position Summary

The Synthetic Molecule Design and Development (SMDD) organization is responsible for the development of synthetic drug substances and drug products from the pre-clinical phase through commercialization. Our scientists and engineers develop innovative technical solutions to advance an existing portfolio that includes small molecules, synthetic peptides, oligonucleotides, and other emerging therapeutic modalities to help bring the next generation of life-changing medicines to patients.

Our SMDD team is looking for experienced and creative candidates with experience in chemistry, manufacturing, and controls (CMC) of oligonucleotides to participate in the development of chemistry in support of scalable and environmentally friendly manufacturing processes. This technical role will support emerging synthetic needs across the rapidly evolving Lilly Genetic Medicines (LGM) portfolio. The scientist will collaborate with a growing team comprising chemists, analysts, and engineers focused on the development and optimization of existing methods and exploration of novel synthetic approaches to oligonucleotides and their conjugates. The position presents an opportunity to lead CMC activities to support clinical trials, product commercialization, and regulatory submissions of oligonucleotide therapeutics. Developing and working with both internal manufacturing (Lilly Medicine Foundry) and external contract manufacturing organizations (CMOs) to support oligonucleotide synthesis, tech transfer, and campaign execution will be important aspects of this role.

Responsibilities

• Bring extensive oligonucleotide CMC expertise to SMDD and grow internal capability through coaching, mentorship, and technical leadership across a diverse portfolio — complex single strands, siRNA, and oligonucleotide conjugates (AOC and PRC).
• Apply modern synthetic organic and nucleic acid chemistry to challenge existing methods, define new manufacturing technologies, and address key CMC challenges across the LGM portfolio.
• Develop and apply impurity control strategies aligned with the current global regulatory climate; address CMC regulatory questions enabling clinical studies and marketing authorization applications. Prior experience in validation activities preferred.
• Provide technical leadership across route design, process development, equipment selection, and scale-up — from laboratory plans through demonstration on development- and commercial-scale equipment, partnering with internal manufacturing (Lilly Medicine Foundry) and external CMOs to deliver robust processes for clinical and commercial supply.
• Demonstrate strong skills with automated reactor platforms and purification technologies and apply them across the oligonucleotide portfolio.
• Collaborate across internal CMC networks (Drug Product Delivery, Project Management, Quality, Manufacturing, and Regulatory) to deliver materials and documentation for clinical trials and regulatory submissions.
• Identify and integrate external chemistry innovations to complement internal capabilities; represent Lilly externally through presentations at symposia and consortia and publications in peer-reviewed journals.
• Contribute novel chemical design and mechanism-based problem solving (e.g., total synthesis, methodology development, oligonucleotide synthesis), reflected in a strong peer-reviewed publication record.
• Lead through ambiguity and change; encourage initiative, accountability, and diverse perspectives across the team.

Basic Qualifications

• PhD in a relevant scientific discipline with 5+ years of relevant industry experience (synthesis, oligonucleotides, solid-phase synthesis, CMC); or
• MS in a relevant scientific discipline with 8+ years of relevant industry experience (synthesis, oligonucleotides, solid-phase synthesis, CMC).
• Experience within the pharmaceutical sector: active ingredient development and associated formulated products; developing chemical processes from mid-development (proof of concept) through commercialization.
• Experience in development and CMC including quality and regulatory interactions.
• Experience with tech transfer of processes into manufacturing operations.

Additional Preferences

• Strong interpersonal skills and a collaborative working style.
• Demonstrated initiative and appropriate risk-taking.
• Demonstrated technical proficiency and ability to create ideas for future work plans.
• Strong technical skills that deliver business value.
• Knowledge and experience with management of a technical project.
• Demonstrated leadership capabilities, especially in a team environment.
• Ability to prioritize multiple activities and manage ambiguity.
• Ability to influence others to promote a positive work environment.
• Demonstrated success in persuasion, influence, and negotiation.

Physical Demands/Travel

• Position Local: Indianapolis, IN; Lilly Technology Center-North (LTC-N)
• The physical demands of this job are consistent with a lab environment.
• Travel: 0 to 10%

Work Environment

This position’s work environment is in a laboratory environment.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

• To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$148,500 - $257,400

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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