Microfluidics / Consumable Engineer

System One; Cambridge (MA); On-site; USD 86,000 - 123,000; Full time

Job summary

System One, Inc. in Boston, MA is seeking a Microfluidics / Consumable Engineer for a contract-to-hire role onsite to engineer the consumables for the manufacturing platform.

The role entails owning end-to-end cartridge design and validation for RNA medicine manufacturing. The candidate should hold an MS/PhD in engineering with a microfluidics focus and have 6+ years of hands-on device design experience, with expertise in low-Reynolds-number flow and fabrication methods such as injection

Qualifications

• MS or PhD in mechanical, chemical, or biomedical engineering with a microfluidics specialization.
• At least six years of experience designing and building microfluidic or milli-fluidic devices that have gone into real use.
• Strong understanding of low-Reynolds-number flow, mixing, pressure drop, residence time, and microfluidic nanoparticle formation, including how mixing parameters impact particle size, polydispersity, and encapsulation efficiency.
• Hands-on fabrication experience across at least two of the listed techniques: injection molding, hot embossing, laser micromachining, CNC micro-milling, film lamination, laser or ultrasonic welding, and pressure-sensitive adhesive bonding.
• Experience in fluidic network design and/or CFD applied to real design decisions.

Responsibilities

• Own the engineering of the consumables for the manufacturing platform.
• Manage the flow path carrying every unit operation of the end-to-end process including DNA template preparation/amplification, purification/filtration, and encapsulation.
• Design channel geometry and hydrodynamics, mixing elements, valve and actuator placement, in-line sensing locations, and fluid-path interfaces to various subsystems.
• Select materials and joining methods compatible with sterilization under ISO 11137.
• Conduct bench de-risking of cartridge unit operations, fabricate the initial cartridge lot, and verify cartridges against set acceptance criteria.

Skills

Microfluidics design

Low-Reynolds flow

Particle encapsulation

Prototype fabrication

Fluidic network design

Education

MS/PhD in engineering

Tools

Injection molding

Hot embossing

Laser micromachining

CNC micro-milling

Film lamination

Job description

Job Title: Microfluidics / Consumable Engineer
Location: Boston, MA
Type: Contract to Hire
Compensation: $75.96
Work Model: Onsite - onsite
Hours: Standard business hours
Security Clearance: Not specified

Overview

Join a growing biotechnology organization in the U.S. that focuses on next-generation RNA medicine manufacturing. The Microfluidics/Consumable Engineer will be responsible for the engineering of the consumables for the manufacturing platform.

Responsibilities

• Own the engineering of the consumables for the manufacturing platform.
• Manage the flow path carrying every unit operation of the end-to-end process including DNA template preparation/amplification, purification/filtration, and encapsulation.
• Design channel geometry and hydrodynamics, mixing elements, valve and actuator placement, in-line sensing locations, and fluid-path interfaces to various subsystems.
• Select materials and joining methods compatible with sterilization under ISO 11137.
• Conduct bench de-risking of cartridge unit operations, fabricate the initial cartridge lot, and verify cartridges against set acceptance criteria.

Requirements

• MS or PhD in mechanical, chemical, or biomedical engineering, or a related discipline with a microfluidics specialization.
• At least six years of experience designing and building microfluidic or milli-fluidic devices that have gone into real use.
• Strong understanding of low-Reynolds-number flow, mixing, pressure drop, residence time, and microfluidic nanoparticle formation, including how mixing parameters impact particle size, polydispersity, and encapsulation efficiency.
• Hands-on fabrication experience across at least two of the following: injection molding, hot embossing, laser micromachining, CNC micro-milling, film lamination, laser or ultrasonic welding, and pressure-sensitive adhesive bonding.
• Experience in fluidic network design and/or CFD applied to real design decisions.

System One, and its subsidiaries including Joulé and Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.

System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.

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