Microfluidics Consumables Engineer – Onsite Boston

System One; Cambridge (MA); On-site; USD 86,000 - 123,000; Full time

Job summary

System One, Inc. in Boston, MA is seeking a Microfluidics / Consumable Engineer for a contract-to-hire role onsite to engineer the consumables for the manufacturing platform.

The role entails owning end-to-end cartridge design and validation for RNA medicine manufacturing. The candidate should hold an MS/PhD in engineering with a microfluidics focus and have 6+ years of hands-on device design experience, with expertise in low-Reynolds-number flow and fabrication methods such as injection

Qualifications

• MS or PhD in mechanical, chemical, or biomedical engineering with a microfluidics specialization.
• At least six years of experience designing and building microfluidic or milli-fluidic devices that have gone into real use.
• Strong understanding of low-Reynolds-number flow, mixing, pressure drop, residence time, and microfluidic nanoparticle formation, including how mixing parameters impact particle size, polydispersity, and encapsulation efficiency.
• Hands-on fabrication experience across at least two of the listed techniques: injection molding, hot embossing, laser micromachining, CNC micro-milling, film lamination, laser or ultrasonic welding, and pressure-sensitive adhesive bonding.
• Experience in fluidic network design and/or CFD applied to real design decisions.

Responsibilities

• Own the engineering of the consumables for the manufacturing platform.
• Manage the flow path carrying every unit operation of the end-to-end process including DNA template preparation/amplification, purification/filtration, and encapsulation.
• Design channel geometry and hydrodynamics, mixing elements, valve and actuator placement, in-line sensing locations, and fluid-path interfaces to various subsystems.
• Select materials and joining methods compatible with sterilization under ISO 11137.
• Conduct bench de-risking of cartridge unit operations, fabricate the initial cartridge lot, and verify cartridges against set acceptance criteria.

Skills

Microfluidics design

Low-Reynolds flow

Particle encapsulation

Prototype fabrication

Fluidic network design

Education

MS/PhD in engineering

Tools

Injection molding

Hot embossing

Laser micromachining

CNC micro-milling

Film lamination

Job description

System One, Inc. in Boston, MA is seeking a Microfluidics / Consumable Engineer for a contract-to-hire role onsite to engineer the consumables for the manufacturing platform.

The role entails owning end-to-end cartridge design and validation for RNA medicine manufacturing. The candidate should hold an MS/PhD in engineering with a microfluidics focus and have 6+ years of hands-on device design experience, with expertise in low-Reynolds-number flow and fabrication methods such as injection